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01 Dec 2020
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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
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Early-onset GDM linked to adverse pregnancy outcomes

04 Jan 2021

Gestational diabetes mellitus (GDM) diagnosed early by oral glucose tolerance test (OGTT) at 18 to 20 gestational weeks predicts maternal and neonatal metabolic disorders as well as pregnancy outcomes, a study has found.

In this prospective cohort study, each of the 522 participants underwent two OGTTs: an early OGTT at 18 to 20 gestational weeks and a standard OGTT at 24 to 28 gestational weeks. The authors analysed the reproducibility between early and standard OGTT. They also compared the maternal and neonatal metabolic disorders and pregnancy outcomes across groups.

All participants completed both the early and standard OGTTs. Glucose values in the early OGTT were not significantly different from those in the standard OGTT (fasting: 4.31±0.41 vs 4.29±0.37 mmol/L; p=0.360; 1-hour: 7.68±1.71 vs 7.66±1.59 mmol/L; p=0.826; 2-hour: 6.69±1.47 vs 6.71±1.39 mmol/L; p=0.800). Early and standard OGTT results had a reproducibility of 74.9 percent.

Glycated haemoglobin, C-peptide, and homeostasis model assessment of insulin resistance in the late gestational period were higher among pregnant women in the GDM group. Neonates born to these mothers were also at greater risk of being large for gestational age (odds ratio [OR], 3.665, 95 percent confidence interval [CI], 1.006–11.91) and more prone to neonatal hyperinsulinaemia (OR, 3.652, 95 percent CI, 1.152–10.533).

“Further randomized controlled trials on the therapeutic efficacy for early-onset GDM will confirm the significance of early screening for GDM.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 4 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
4 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.