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Early melanoma treatment improves outcomes

21 Dec 2017

Speedy treatment of stage I melanoma is likely to result in improved outcomes, suggests a recent study.

Multivariate analysis revealed that patients in all stages who were treated between 90 and 119 days following biopsy (hazard ratio [HR], 1.09; 95 percent CI, 1.01‒1.18) and >119 days (HR, 1.12; 1.02‒1.22) had a greater risk for mortality vs those treated within 30 days of biopsy.

A subgroup analysis of patients with stage I melanoma showed a higher mortality risk among those treated within 30 to 59 days (HR, 1.05; 1.01‒1.1), 60 to 89 days (HR, 1.16; 1.07‒1.25), 90 to 119 days (HR, 1.29; 1.12‒1.48), and >119 days after biopsy (HR, 1.41; 1.21‒1.65). In stages II and III, surgical timing had no impact on survival.

“Patient concern for receiving immediate treatment often exceeds surgeon or hospital availability, requiring establishment of a safe window for melanoma surgery,” researchers said.

In this study that examined the impact of time to definitive melanoma surgery on overall survival, patients with stage I to III cutaneous melanoma and with available time to definitive surgery and overall survival were identified using the National Cancer Database (n=153,218). Researchers compared variables using the t test and chi-square test. Cox regression was used for multivariate analysis.

The findings of this study should be viewed in light of certain limitations, such as the absence of melanoma-specific survival, according to researchers.

An earlier study showed that time interval of up to 3 months between melanoma diagnosis and sentinel node (SN) biopsy had no impact on 5-year survival or SN positivity rate. This finding can be used to counsel patients and remove strict time limits from melanoma guidelines, said researchers. [Eur J Cancer 2016;67:164-173]

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Most Read Articles
6 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 3 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
5 days ago
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
3 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.