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Early melanoma treatment improves outcomes

21 Dec 2017

Speedy treatment of stage I melanoma is likely to result in improved outcomes, suggests a recent study.

Multivariate analysis revealed that patients in all stages who were treated between 90 and 119 days following biopsy (hazard ratio [HR], 1.09; 95 percent CI, 1.01‒1.18) and >119 days (HR, 1.12; 1.02‒1.22) had a greater risk for mortality vs those treated within 30 days of biopsy.

A subgroup analysis of patients with stage I melanoma showed a higher mortality risk among those treated within 30 to 59 days (HR, 1.05; 1.01‒1.1), 60 to 89 days (HR, 1.16; 1.07‒1.25), 90 to 119 days (HR, 1.29; 1.12‒1.48), and >119 days after biopsy (HR, 1.41; 1.21‒1.65). In stages II and III, surgical timing had no impact on survival.

“Patient concern for receiving immediate treatment often exceeds surgeon or hospital availability, requiring establishment of a safe window for melanoma surgery,” researchers said.

In this study that examined the impact of time to definitive melanoma surgery on overall survival, patients with stage I to III cutaneous melanoma and with available time to definitive surgery and overall survival were identified using the National Cancer Database (n=153,218). Researchers compared variables using the t test and chi-square test. Cox regression was used for multivariate analysis.

The findings of this study should be viewed in light of certain limitations, such as the absence of melanoma-specific survival, according to researchers.

An earlier study showed that time interval of up to 3 months between melanoma diagnosis and sentinel node (SN) biopsy had no impact on 5-year survival or SN positivity rate. This finding can be used to counsel patients and remove strict time limits from melanoma guidelines, said researchers. [Eur J Cancer 2016;67:164-173]

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4 days ago
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
2 days ago
In patients with atrial fibrillation (AF) and stable coronary artery disease (CAD), rivaroxaban monotherapy is noninferior to combination treatment with an antiplatelet therapy in terms of cutting the risk of cardiovascular events and mortality, according to data from the AFIRE trial.
Elvira Manzano, 3 days ago
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