Most Read Articles
09 Dec 2016
All patients with acne are potentially at risk of scarring. Professor Goh Chee Leok addresses this issue by focussing on preventing the development of scars in his talk at the 41st Annual Meeting of the Dermatological Society of Malaysia held in Kuching, Sarawak.
11 Nov 2016
Non-purulent cellulitis and cutaneous abscesses, despite both belonging to the spectrum of skin and soft-tissue infections, are aetiologically different, a new study reports. Further, atypical bacteria may be present in cellulitis patients, indicating novel disease mechanisms.
05 Jan 2017
Olumacostat glasaretil (OG) appears to be effective and is well tolerated in patients with moderate to severe facial acne vulgaris, suggesting the need for further development, according to a new study.
Tristan Manalac, 10 Mar 2018
Cost of treatment is a major driver of patients’ primary nonadherence to acne medication, according to a recent study. Physicians who openly discuss medications costs and provide a plan of action in case patients are unable to fill prescriptions may improve treatment adherence.

Early melanoma treatment improves outcomes

21 Dec 2017

Speedy treatment of stage I melanoma is likely to result in improved outcomes, suggests a recent study.

Multivariate analysis revealed that patients in all stages who were treated between 90 and 119 days following biopsy (hazard ratio [HR], 1.09; 95 percent CI, 1.01‒1.18) and >119 days (HR, 1.12; 1.02‒1.22) had a greater risk for mortality vs those treated within 30 days of biopsy.

A subgroup analysis of patients with stage I melanoma showed a higher mortality risk among those treated within 30 to 59 days (HR, 1.05; 1.01‒1.1), 60 to 89 days (HR, 1.16; 1.07‒1.25), 90 to 119 days (HR, 1.29; 1.12‒1.48), and >119 days after biopsy (HR, 1.41; 1.21‒1.65). In stages II and III, surgical timing had no impact on survival.

“Patient concern for receiving immediate treatment often exceeds surgeon or hospital availability, requiring establishment of a safe window for melanoma surgery,” researchers said.

In this study that examined the impact of time to definitive melanoma surgery on overall survival, patients with stage I to III cutaneous melanoma and with available time to definitive surgery and overall survival were identified using the National Cancer Database (n=153,218). Researchers compared variables using the t test and chi-square test. Cox regression was used for multivariate analysis.

The findings of this study should be viewed in light of certain limitations, such as the absence of melanoma-specific survival, according to researchers.

An earlier study showed that time interval of up to 3 months between melanoma diagnosis and sentinel node (SN) biopsy had no impact on 5-year survival or SN positivity rate. This finding can be used to counsel patients and remove strict time limits from melanoma guidelines, said researchers. [Eur J Cancer 2016;67:164-173]

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Most Read Articles
09 Dec 2016
All patients with acne are potentially at risk of scarring. Professor Goh Chee Leok addresses this issue by focussing on preventing the development of scars in his talk at the 41st Annual Meeting of the Dermatological Society of Malaysia held in Kuching, Sarawak.
11 Nov 2016
Non-purulent cellulitis and cutaneous abscesses, despite both belonging to the spectrum of skin and soft-tissue infections, are aetiologically different, a new study reports. Further, atypical bacteria may be present in cellulitis patients, indicating novel disease mechanisms.
05 Jan 2017
Olumacostat glasaretil (OG) appears to be effective and is well tolerated in patients with moderate to severe facial acne vulgaris, suggesting the need for further development, according to a new study.
Tristan Manalac, 10 Mar 2018
Cost of treatment is a major driver of patients’ primary nonadherence to acne medication, according to a recent study. Physicians who openly discuss medications costs and provide a plan of action in case patients are unable to fill prescriptions may improve treatment adherence.