Early-life exposures affect BP in children
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.
Systolic BP decreased with facility density (β change for an interquartile-range increase in exposure: −1.7 mm Hg, 95 percent CI, −2.5 to −0.8 mm Hg), maternal concentrations of polychlorinated biphenyl 118 (−1.4 mm Hg, −2.6 to −0.2 mm Hg) and child concentrations of dichlorodiphenyldichloroethylene (DDE; −1.6 mm Hg, −2.4 to −0.7 mm Hg), hexachlorobenzene (−1.5 mm Hg, −2.4 to −0.6 mm Hg) and mono−benzyl phthalate (−0.7 mm Hg, −1.3 to −0.1 mm Hg).
On the other hand, systolic BP increased with outdoor temperature during pregnancy (1.6 mm Hg, 0.2–2.9 mm Hg), high fish intake during pregnancy (2.0 mm Hg, 0.4–3.5 mm Hg), maternal cotinine concentrations (1.2 mm Hg, –0.3 to 2.8 mm Hg) and child perfluorooctanoate concentrations (0.9 mm Hg, 0.1–1.6 mm Hg).
Diastolic BP decreased with outdoor temperature at examination (–1.4 mm Hg, –2.3 to –0.5 mm Hg) and child DDE concentrations (–1.1 mm Hg, –1.9 to –0.3 mm Hg), and increased with maternal bisphenol-A concentrations (0.7 mm Hg, 0.1–1.4 mm Hg), high fish intake during pregnancy (1.2 mm Hg, –0.2 to 2.7 mm Hg) and child copper concentrations (0.9 mm Hg, 0.3–1.16 mm Hg).
The authors measured systolic and diastolic BP among 1,277 children from the European HELIX cohort aged 6–11 years. Prenatal (n=89) and postnatal (n=128) exposures were as follows: air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals and lifestyles.
The following methods, adjusted for confounders, were applied: an exposome-wide association study considering the exposures independently and the deletion-substitution-addition algorithm considering all the exposures simultaneously.