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Early-life exposures affect BP in children

11 Sep 2019

Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.

Systolic BP decreased with facility density (β change for an interquartile-range increase in exposure: −1.7 mm Hg, 95 percent CI, −2.5 to −0.8 mm Hg), maternal concentrations of polychlorinated biphenyl 118 (−1.4 mm Hg, −2.6 to −0.2 mm Hg) and child concentrations of dichlorodiphenyldichloroethylene (DDE; −1.6 mm Hg, −2.4 to −0.7 mm Hg), hexachlorobenzene (−1.5 mm Hg, −2.4 to −0.6 mm Hg) and mono−benzyl phthalate (−0.7 mm Hg, −1.3 to −0.1 mm Hg).

On the other hand, systolic BP increased with outdoor temperature during pregnancy (1.6 mm Hg, 0.2–2.9 mm Hg), high fish intake during pregnancy (2.0 mm Hg, 0.4–3.5 mm Hg), maternal cotinine concentrations (1.2 mm Hg, –0.3 to 2.8 mm Hg) and child perfluorooctanoate concentrations (0.9 mm Hg, 0.1–1.6 mm Hg).

Diastolic BP decreased with outdoor temperature at examination (–1.4 mm Hg, –2.3 to –0.5 mm Hg) and child DDE concentrations (–1.1 mm Hg, –1.9 to –0.3 mm Hg), and increased with maternal bisphenol-A concentrations (0.7 mm Hg, 0.1–1.4 mm Hg), high fish intake during pregnancy (1.2 mm Hg, –0.2 to 2.7 mm Hg) and child copper concentrations (0.9 mm Hg, 0.3–1.16 mm Hg).

The authors measured systolic and diastolic BP among 1,277 children from the European HELIX cohort aged 6–11 years. Prenatal (n=89) and postnatal (n=128) exposures were as follows: air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals and lifestyles.

The following methods, adjusted for confounders, were applied: an exposome-wide association study considering the exposures independently and the deletion-substitution-addition algorithm considering all the exposures simultaneously.

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Most Read Articles
Tristan Manalac, 30 Jan 2020
Despite being mostly sufficiently active, obese and overweight children with congenital heart disease (CHD) still need to increase physical activity levels, according to a recent study.
Pearl Toh, 5 days ago
Toddlers with a longer screen viewing time were more sedentary and spent less time engaged in physical activity later in life at age 5.5 years, according to the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study — supporting the hypothesis that screen viewing may have a negative influence on health by displacing physical activity.
10 Feb 2020
Regardless of the type, disordered eating behaviours may lead to a higher body mass index (BMI) in the long run in adolescents, a recent study has shown.
Audrey Abella, 06 Feb 2020
Clinical hypnosis is an acceptable, feasible, and promising complementary therapy in adolescents with Crohn’s disease (CD), according to data presented at Crohn’s and Colitis 2020.