Most Read Articles
28 Feb 2018
Maternal influenza and Tdap (tetanus toxoid, reduced diphtheria toxoid, acellular pertussis) vaccinations during pregnancy do not increase the risk for hospitalization or death in infants, a study has shown.
Roshini Claire Anthony, 12 May 2020

Adults who develop peanut allergy in adulthood are less likely to receive a physician diagnosis of their allergy or use epinephrine compared with those with childhood-onset peanut allergy, according to a study from the US.

Early-life exposures affect BP in children

11 Sep 2019

Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.

Systolic BP decreased with facility density (β change for an interquartile-range increase in exposure: −1.7 mm Hg, 95 percent CI, −2.5 to −0.8 mm Hg), maternal concentrations of polychlorinated biphenyl 118 (−1.4 mm Hg, −2.6 to −0.2 mm Hg) and child concentrations of dichlorodiphenyldichloroethylene (DDE; −1.6 mm Hg, −2.4 to −0.7 mm Hg), hexachlorobenzene (−1.5 mm Hg, −2.4 to −0.6 mm Hg) and mono−benzyl phthalate (−0.7 mm Hg, −1.3 to −0.1 mm Hg).

On the other hand, systolic BP increased with outdoor temperature during pregnancy (1.6 mm Hg, 0.2–2.9 mm Hg), high fish intake during pregnancy (2.0 mm Hg, 0.4–3.5 mm Hg), maternal cotinine concentrations (1.2 mm Hg, –0.3 to 2.8 mm Hg) and child perfluorooctanoate concentrations (0.9 mm Hg, 0.1–1.6 mm Hg).

Diastolic BP decreased with outdoor temperature at examination (–1.4 mm Hg, –2.3 to –0.5 mm Hg) and child DDE concentrations (–1.1 mm Hg, –1.9 to –0.3 mm Hg), and increased with maternal bisphenol-A concentrations (0.7 mm Hg, 0.1–1.4 mm Hg), high fish intake during pregnancy (1.2 mm Hg, –0.2 to 2.7 mm Hg) and child copper concentrations (0.9 mm Hg, 0.3–1.16 mm Hg).

The authors measured systolic and diastolic BP among 1,277 children from the European HELIX cohort aged 6–11 years. Prenatal (n=89) and postnatal (n=128) exposures were as follows: air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals and lifestyles.

The following methods, adjusted for confounders, were applied: an exposome-wide association study considering the exposures independently and the deletion-substitution-addition algorithm considering all the exposures simultaneously.

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Most Read Articles
28 Feb 2018
Maternal influenza and Tdap (tetanus toxoid, reduced diphtheria toxoid, acellular pertussis) vaccinations during pregnancy do not increase the risk for hospitalization or death in infants, a study has shown.
Roshini Claire Anthony, 12 May 2020

Adults who develop peanut allergy in adulthood are less likely to receive a physician diagnosis of their allergy or use epinephrine compared with those with childhood-onset peanut allergy, according to a study from the US.