Most Read Articles
Stephen Padilla, 02 Oct 2019
Baseline body mass index (BMI) and, to a lesser extent, school socioeconomic status are associated with subsequent weight status in schoolchildren, according to a study. Lifestyle behaviours show a lower effect as compared with prior BMI, but children with a healthier lifestyle have a reduced risk of overweight and obesity at follow-up.
04 Sep 2019
The use of iron-fortified formula milk in infants between 6–12 months of age may lead to poorer cognitive outcomes, a recent study has shown.
Jairia Dela Cruz, 04 Sep 2019
Parenteral antibiotic therapy duration for bacteraemic urinary tract infection (UTI) in young infants may be safely shortened, according to a recent study showing that recurrence and readmission or emergency department revisitation rates are comparable between a ≤7-day and a longer therapy course.
Audrey Abella, 07 May 2019
Use of electronic vapour products (EVP), or vaping, has been associated with an increased likelihood of engaging in sexual and substance-use risk behaviours among US teenagers, according to data from the 2017 National Youth Risk Behaviour Survey presented at the Paediatric Academic Societies (PAS) 2019 Meeting.

Early-life exposures affect BP in children

11 Sep 2019

Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.

Systolic BP decreased with facility density (β change for an interquartile-range increase in exposure: −1.7 mm Hg, 95 percent CI, −2.5 to −0.8 mm Hg), maternal concentrations of polychlorinated biphenyl 118 (−1.4 mm Hg, −2.6 to −0.2 mm Hg) and child concentrations of dichlorodiphenyldichloroethylene (DDE; −1.6 mm Hg, −2.4 to −0.7 mm Hg), hexachlorobenzene (−1.5 mm Hg, −2.4 to −0.6 mm Hg) and mono−benzyl phthalate (−0.7 mm Hg, −1.3 to −0.1 mm Hg).

On the other hand, systolic BP increased with outdoor temperature during pregnancy (1.6 mm Hg, 0.2–2.9 mm Hg), high fish intake during pregnancy (2.0 mm Hg, 0.4–3.5 mm Hg), maternal cotinine concentrations (1.2 mm Hg, –0.3 to 2.8 mm Hg) and child perfluorooctanoate concentrations (0.9 mm Hg, 0.1–1.6 mm Hg).

Diastolic BP decreased with outdoor temperature at examination (–1.4 mm Hg, –2.3 to –0.5 mm Hg) and child DDE concentrations (–1.1 mm Hg, –1.9 to –0.3 mm Hg), and increased with maternal bisphenol-A concentrations (0.7 mm Hg, 0.1–1.4 mm Hg), high fish intake during pregnancy (1.2 mm Hg, –0.2 to 2.7 mm Hg) and child copper concentrations (0.9 mm Hg, 0.3–1.16 mm Hg).

The authors measured systolic and diastolic BP among 1,277 children from the European HELIX cohort aged 6–11 years. Prenatal (n=89) and postnatal (n=128) exposures were as follows: air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals and lifestyles.

The following methods, adjusted for confounders, were applied: an exposome-wide association study considering the exposures independently and the deletion-substitution-addition algorithm considering all the exposures simultaneously.

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Most Read Articles
Stephen Padilla, 02 Oct 2019
Baseline body mass index (BMI) and, to a lesser extent, school socioeconomic status are associated with subsequent weight status in schoolchildren, according to a study. Lifestyle behaviours show a lower effect as compared with prior BMI, but children with a healthier lifestyle have a reduced risk of overweight and obesity at follow-up.
04 Sep 2019
The use of iron-fortified formula milk in infants between 6–12 months of age may lead to poorer cognitive outcomes, a recent study has shown.
Jairia Dela Cruz, 04 Sep 2019
Parenteral antibiotic therapy duration for bacteraemic urinary tract infection (UTI) in young infants may be safely shortened, according to a recent study showing that recurrence and readmission or emergency department revisitation rates are comparable between a ≤7-day and a longer therapy course.
Audrey Abella, 07 May 2019
Use of electronic vapour products (EVP), or vaping, has been associated with an increased likelihood of engaging in sexual and substance-use risk behaviours among US teenagers, according to data from the 2017 National Youth Risk Behaviour Survey presented at the Paediatric Academic Societies (PAS) 2019 Meeting.