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Early LGG supplementation ineffective in eczema, asthma prevention

02 Sep 2017

Early Lactobacillus rhamnosus GG (LGG) supplementation does not appear to be effective in the prevention of eczema or asthma development at 2 years of age in high-risk infants, according to a study.

The study randomized 184 infants to receive a daily capsule containing 10 billion colony-forming units of LGG plus 225 mg of inulin (probiotic; n=92; mean gestational age 39 weeks; 48 percent male) or a capsule containing 325 mg of inulin alone (control; n=92; mean gestational age 38.9 weeks; 52 percent male) for the first 6 months of life.

Survival analysis was used to estimate disease incidences in the presence or absence of LGG, as well as the efficacy of the probiotic in delaying or preventing such diseases.

Infants were accrued over a 6-year period, yielding a median follow-up duration of 4.6 years and with 95 percent of infants followed for at least 2 years. Resulting data revealed that at 2 years of age, the estimated cumulative incidence of eczema was 30.9 percent (95 percent CI, 21.4 to 40.4) in the control group vs 28.7 percent (19.4 to 38.0) in the LGG group. The hazard ratio for eczema was 0.95 (0.59 to 1.53; p=0.83).

At 5 years of age, the cumulative incidence of asthma was 17.4 percent (7.6 to 27.1) in the control group vs 9.7 percent (2.7 to 16.6) in LGG, with a hazard ratio of 0.88 (0.41 to 1.87; p=0.25).

Environmental factors during early infancy can influence the immune system development and subsequent risk for allergic disease, with the hygiene hypothesis suggesting that the absence of infectious exposure at a critical point in such development results in a greater risk of later development of atopic disease or asthma. Early infant supplementation with specific probiotic strains is believed to be a potential mechanism to exploit the hygiene hypothesis and influence the risk of allergic disease in early life. [Sci Transl Med 2015;7:307ra152]

However, the present data do not support the use of LGG probiotic supplementation during the first 6 months of life for the prevention of eczema or asthma in children at high risk of these medical conditions, researchers said. 

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Most Read Articles
01 Jul 2013

Acne is particularly prevalent during adolescence, and some teenagers will face an on-going battle with this common skin condition.

27 Apr 2017
Lifestyle and physiological factors determine the wrinkling patterns between men and women, a recent study suggests. Less wrinkling is associated with sunburn tendency in men and with female pattern hair loss in women, whereas increased wrinkling is linked to age and current smoking in both genders.
01 Jul 2014

New drug applications approved by US FDA as of 1-15 July which includes New Molecular Entities (NMEs) and new biologics. It includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

01 Mar 2017
The use of multiple dissection planes in endoscope-assisted facelifts of the frontal and temporal areas may be helpful for selected patients, a Singapore study reveals.