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20 Jun 2020
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Early ibuprofen exposure conveys elevated risk of BPD in extremely preterm babies

07 Feb 2020

The risk of developing bronchopulmonary dysplasia (BPD) appears to be twofold higher in neonates exposed to ibuprofen during the first days of life, a study has found.

Researchers examined the medical records of 203 extremely premature infants. There were 87 infants (42.8 percent) who received at least one course of ibuprofen for the treatment of patent ductus arteriosus (PDA), with treatment resulting in a successful closure rate of 35.6 percent (n=31) within 48 hours after treatment completion. The median age at the first dose was 6.5 days, with median feeding volume of 1 ml per feeding.

Sixty-two infants (30.5 percent) developed BPD, and the proportion was significantly higher in the group of those with vs without early exposure to ibuprofen (42.5 percent vs 21.6 percent; p=0.001).

In multivariable regression models, the risk of BPD showed a positive association with ibuprofen exposure (odds ratio [OR], 2.296, 95 percent confidence interval [CI], 1.166–4.522; p=0.016). Moreover, there was a trend toward increased BPD risk in those with successful PDA closure after ibuprofen treatment than in nontreated infants (32.3 percent vs 20.2 percent; p=0.162).

While unclear, the mechanisms underlying the association between early ibuprofen exposure and heightened BPD risk may involve the antiangiogenetic effect of the drug, according to the researchers, adding that such is possible among extremely premature infants who are more vulnerable to blocked angiogenesis.

However, the researchers noted that multiple courses of ibuprofen treatment did not lead to a significantly increased risk of BPD in the current study, which may be attributed to the small sample size. Therefore, more studies with larger populations are warranted to further examine the possible negative effects of ibuprofen exposure on the developing premature lung.

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Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 4 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
3 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 2 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.