Most Read Articles
18 Aug 2018
Despite the absence of a substance use problem, regular cannabis use is associated with psychosocial impairment among adolescents and young adults, a study suggests. On the other hand, regular users with cannabis use disorder appear to exhibit high psychiatric comorbidity and more severe psychosocial impairment.
07 Sep 2018
Children with Down syndrome appear to have an elevated risk of developing severe respiratory syncytial virus (RSV) infection, a study has found.
21 Mar 2018
During the Kuala Lumpur International Neonatology Conference held in conjunction with the World Prematurity Day 2017, Dato Dr Musa Mohd Nordin spoke on the importance of immunizing children with the diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine. He highlighted the role of Hexaxim® as a fully liquid, ready-to-use, 6-in-1 (including hepatitis B) vaccine for the primary and booster vaccinations of infants and toddlers. Meanwhile, Dr Yong Junina Fadzil discussed the benefits of quadrivalent influenza vaccines (QIVs) in providing children with broader protection against influenza B viruses.
Jairia Dela Cruz, 01 Sep 2018
Tight glycaemic control does not yield significant short-term survival gains and risk reductions for infections when compared with a conventional glucose-lowering strategy in critically ill patients in the paediatric intensive care unit, according to a meta-analysis.

Early caffeine initiation tied to better outcomes in preterm infants with RDS

02 Jan 2018
Caffeine can cause several unwanted side effects which come with the over-stimulation of the central nervous system.

In preterm infants with respiratory distress syndrome (RDS), early initiation of caffeine therapy is associated with lower incidences of patent ductus arteriosus (PDA) and intraventricular haemorrhage (IVH), a recent study shows.

The researchers evaluated the complications of prematurity and need for ventilator support in 844 preterm infants. Early caffeine therapy, initiated within the first 24 hours of life, was reported in 80.1 percent (n=676) of the infants and was associated with reduced need for ventilation.

For instance, significantly less infants in the early caffeine initiation group needed invasive ventilation than in the late initiation group (n=19.9 percent; 168; 71.3 vs 83.2 percent; p=0.0165). Total duration of mechanical ventilation was also significantly shorter in the early than in the late initiation group (5±11.1 vs 10.8±14.6 days; p=0.000).

The incidence rate of PDA was significantly lower in the early than in the late caffeine therapy initiation group (25 vs 37 percent; p=0.0427). ­Early initiation was also associated with a significantly lower risk of PDA (odds ratio [OR], 0.5686; 95 percent CI, 0.3395–0.9523).

In terms of secondary endpoints, IVH was significantly more common in the late than in the early initiation group (60.1 vs 42.1 percent; p=0.0039), and early caffeine initiation was associated with a significantly reduced IVH risk (OR, 0.4827; 0.2999–0.7787).

In contrast, the timing of caffeine therapy initiation had no significant impact on the occurrence of grade 3 or 4 IVH and on mortality rates, which were statistically similar between the two groups before hospital discharge (8.6 vs 8.5 percent).

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Most Read Articles
18 Aug 2018
Despite the absence of a substance use problem, regular cannabis use is associated with psychosocial impairment among adolescents and young adults, a study suggests. On the other hand, regular users with cannabis use disorder appear to exhibit high psychiatric comorbidity and more severe psychosocial impairment.
07 Sep 2018
Children with Down syndrome appear to have an elevated risk of developing severe respiratory syncytial virus (RSV) infection, a study has found.
21 Mar 2018
During the Kuala Lumpur International Neonatology Conference held in conjunction with the World Prematurity Day 2017, Dato Dr Musa Mohd Nordin spoke on the importance of immunizing children with the diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine. He highlighted the role of Hexaxim® as a fully liquid, ready-to-use, 6-in-1 (including hepatitis B) vaccine for the primary and booster vaccinations of infants and toddlers. Meanwhile, Dr Yong Junina Fadzil discussed the benefits of quadrivalent influenza vaccines (QIVs) in providing children with broader protection against influenza B viruses.
Jairia Dela Cruz, 01 Sep 2018
Tight glycaemic control does not yield significant short-term survival gains and risk reductions for infections when compared with a conventional glucose-lowering strategy in critically ill patients in the paediatric intensive care unit, according to a meta-analysis.