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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
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Early breast cancer screening helps prevent death in childhood cancer survivors

19 Jul 2020

Annual breast screening initiated at ages 25–30 years with magnetic resonance imaging (MRI), with or without mammography, may lower breast cancer mortality by at least 50 percent in survivors of childhood cancer, suggests a study.

This collaborative simulation modeling used two Cancer Intervention and Surveillance Modeling Network breast cancer models and included women aged 20 years with a history of chest radiotherapy. Participants underwent annual MRI with or without mammography, starting at age 25, 30, or 35 years.

Outcomes measured included breast cancer deaths averted, false-positive screening results, benign biopsy results, and incremental cost-effectiveness ratios (ICERs).

Base-case analysis revealed a lifetime breast cancer mortality risk of 10–11 percent without screening across models. Initiation of breast cancer screening at age 25 years prevented most deaths (annual mammography with MRI: deaths averted, 56–71 percent; annual MRI without mammography: deaths averted, 56–62 percent) compared with no screening. Both strategies had the most screening tests, false-positive screening results, and benign biopsy results.

Screening initiated at age 30 years was preferred for an ICER threshold of <$100,000 per quality-adjusted life-year gained.

On sensitivity analysis, the benefit of adding mammography to MRI increased in both models, with the assumption of lower screening performance. Moreover, the preferred age for screening initiation remained unchanged.

One limitation of this study was that elevated breast cancer risk was based on survivors diagnosed with childhood cancer between 1970 and 1986, according to the investigators.

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Most Read Articles
4 days ago
Among postmenopausal women, short sleep duration and depression contribute to increased fall accidents, as reported in a study.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
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