Most Read Articles
Stephen Padilla, 02 Oct 2019
Baseline body mass index (BMI) and, to a lesser extent, school socioeconomic status are associated with subsequent weight status in schoolchildren, according to a study. Lifestyle behaviours show a lower effect as compared with prior BMI, but children with a healthier lifestyle have a reduced risk of overweight and obesity at follow-up.
04 Sep 2019
The use of iron-fortified formula milk in infants between 6–12 months of age may lead to poorer cognitive outcomes, a recent study has shown.
Audrey Abella, 07 May 2019
Use of electronic vapour products (EVP), or vaping, has been associated with an increased likelihood of engaging in sexual and substance-use risk behaviours among US teenagers, according to data from the 2017 National Youth Risk Behaviour Survey presented at the Paediatric Academic Societies (PAS) 2019 Meeting.
Jairia Dela Cruz, 04 Sep 2019
Parenteral antibiotic therapy duration for bacteraemic urinary tract infection (UTI) in young infants may be safely shortened, according to a recent study showing that recurrence and readmission or emergency department revisitation rates are comparable between a ≤7-day and a longer therapy course.

Early antibiotic exposure may predispose infants to childhood asthma

09 Jul 2019

Antibiotic use during infancy may increase the risk of developing childhood asthma in a dose-dependent fashion, a study has found.

Researchers examined a cohort of 152,622 children enrolled in the Tennessee Medicaid Program, every one of whom were singletons, born at term and had birthweight above the low threshold. They obtained data on infant antibiotic exposure and childhood asthma diagnosis from prescription fills and healthcare encounter claims.

In the cohort, 79 percent of the children had at least one antibiotic prescription fill during infancy (median age at the first fill, 229 days). Most prescribed antibiotics were narrow spectrum (67.6 percent), of oral formulation (96.8 percent) and had anaerobic activity (83.5 percent). Penicillin was the most commonly prescribed class of antibiotics (68.1 percent), with amoxicillin being the single most frequently given (52.8 percent).

Multivariable logistic regression models showed that infant antibiotic use was associated with increased likelihood of developing childhood asthma in a dose-dependent manner. Specifically, the odds increased by 20 percent for each additional antibiotic prescription filled (adjusted odds ratio [aOR], 1.20, 95 percent CI, 1.19–1.20). This significant dose-dependent relationship persisted after additionally controlling for timing and type of antibiotics.

Furthermore, broad-spectrum only antibiotic fills were associated with greater odds of developing asthma compared with narrow-spectrum only fills (aOR, 1.10, 1.05–1.19). There was no significant relationship between timing, formulation, anaerobic coverage, and class of antibiotics and childhood asthma.

The findings contribute important insights into specific aspects of infant antibiotic exposure, the researchers said. Physicians should therefore carefully weigh the risks and benefits of antibiotic use in infants before administration, considering possible alternative treatment strategies when available.

Future studies should focus on how the adverse effects of antibiotics could be prevented when their use is required, they added.

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Most Read Articles
Stephen Padilla, 02 Oct 2019
Baseline body mass index (BMI) and, to a lesser extent, school socioeconomic status are associated with subsequent weight status in schoolchildren, according to a study. Lifestyle behaviours show a lower effect as compared with prior BMI, but children with a healthier lifestyle have a reduced risk of overweight and obesity at follow-up.
04 Sep 2019
The use of iron-fortified formula milk in infants between 6–12 months of age may lead to poorer cognitive outcomes, a recent study has shown.
Audrey Abella, 07 May 2019
Use of electronic vapour products (EVP), or vaping, has been associated with an increased likelihood of engaging in sexual and substance-use risk behaviours among US teenagers, according to data from the 2017 National Youth Risk Behaviour Survey presented at the Paediatric Academic Societies (PAS) 2019 Meeting.
Jairia Dela Cruz, 04 Sep 2019
Parenteral antibiotic therapy duration for bacteraemic urinary tract infection (UTI) in young infants may be safely shortened, according to a recent study showing that recurrence and readmission or emergency department revisitation rates are comparable between a ≤7-day and a longer therapy course.