Most Read Articles
Tristan Manalac, 11 Jul 2018
Gestational exposure to grain products fortified with folic acid appears to be linked to a lower risk of psychosis in offspring, according to a recent study.
Pearl Toh, 10 Jul 2018
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.
4 days ago
Chocolate consumption is not associated with risk of coronary heart disease (CHD), stroke or both combined in postmenopausal women free of pre-existing major chronic disease, a study suggests.
Pearl Toh, 5 days ago
More intensive lowering of LDL-C levels was associated with a progressively greater survival benefit than less intensive approach, when the baseline LDL-C levels were ≥100 mg/dL, reveals a meta-analysis of 34 randomized trials.

Early abiraterone acetate treatment improves outcomes in CRPC patients

28 Feb 2018

In chemotherapy-naïve castrate-resistant prostate cancer (CRPC) patients, first- and second-line administration of abiraterone acetate (AA) treatment leads to favourable outcomes, a recent Japan study suggests.

Researchers retrospectively analysed the records of 69 CRPC patients who received AA treatment and classified them into two: the early group, who received AA as first- or second-line treatment (n=24), and the deferred group, who received AA as a third-line or later treatment (n=45).

In unadjusted analyses, only the timing of AA treatment was significantly associated with progression-free survival (PFS), such that those in the early group had better outcomes than those in the deferred group (hazard ratio [HR], 3.29; 95 percent CI, 1.66–6.51; p<0.001).

Adjusting for potential confounders did not attenuate the relationship. Although to a slightly lesser degree, early AA treatment remained significantly correlated with better PFS outcomes (HR, 2.99; 1.35–6.64; p<0.01).

Within the early group, there were no significant differences in outcomes between those who received AA as first- or second-line treatment. That is, patients treated first- or second-line treatment were statistically comparable in terms of prostate-specific antigen response, overall survival and PFS. All participants who received AA as second-line treatment were given flutamide as first-line therapy.

Five patients reported grade 3 adverse events, three of whom had hepatic function. Hypokalaemia and thrombocytopaenia were reported in one patient each. Other adverse events reported were either grade 1 or 2, the most common of which was an increase in alanine aminotransferase or aspartate aminotransferase levels.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Oncology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Tristan Manalac, 11 Jul 2018
Gestational exposure to grain products fortified with folic acid appears to be linked to a lower risk of psychosis in offspring, according to a recent study.
Pearl Toh, 10 Jul 2018
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.
4 days ago
Chocolate consumption is not associated with risk of coronary heart disease (CHD), stroke or both combined in postmenopausal women free of pre-existing major chronic disease, a study suggests.
Pearl Toh, 5 days ago
More intensive lowering of LDL-C levels was associated with a progressively greater survival benefit than less intensive approach, when the baseline LDL-C levels were ≥100 mg/dL, reveals a meta-analysis of 34 randomized trials.