Most Read Articles
06 Jun 2019
Treatment with probiotics falls short of improving gastrointestinal (GI) symptoms in patients with systemic sclerosis, a study has shown.
11 May 2020
A number of patients with coronavirus disease 2019 (COVID-19) present with diarrhoea, and this group may suffer discomfort longer and show persistent positive SARS-CoV-2 in stool specimens as compared with patients who do not have the symptom, as shown in a study.
Stephen Padilla, 28 Oct 2019
Any manner of early postoperative diet delivered into the gastrointestinal tract (GIT) following colorectal surgery will help stimulate gut motility, leading to an earlier return of bowel function and a shorter length of hospital stay (LOS), according to a systematic review and meta-analysis.
11 May 2020
Antireflux surgery results in improved quality of life (QOL) and reduced oesophageal acid exposure in neurologically normal (NN) and impaired (NI) children in the short and medium term, according to the results of a systematic review.

Earlier ALT normalization during antiviral treatment tied to reduced HCC risk in CHB

12 Mar 2020
Hepatitis B is still widely prevalent worldwide despite effective vaccination programmes in many countries.

Earlier normalization of serum alanine aminotransferase (ALT) levels in patients with chronic hepatitis B (CHB) who initiated treatment with entecavir or tenofovir correlates with a proportionally lower risk of hepatocellular carcinoma (HCC), regardless of fatty liver or cirrhosis at baseline and on-treatment virological response (VR), according to a recent study.

The investigators performed landmark analysis and time-dependent Cox analysis in 4,639 CHB patients treated with entecavir or tenofovir. Normal ALT was defined as ≤35 U/L in men and ≤25 U/L in women; VR was defined as serum hepatitis B virus DNA <15 IU/mL.

Of the patients, 509 (11.0 percent) developed HCC during a median 5.6 years of treatment. ALT normalization occurred in 65.6 percent of patients at 1 year and 81.9 percent at 2 years. It also correlated with a significantly reduced risk of HCC in landmark (p<0.001) and time-dependent Cox analyses (adjusted hazard ratio [AHR], 0.57; p<0.001).

Delayed ALT normalization at 6–12 (AHR, 1.40), 12–24 (AHR, 1.75) and >24 months (AHR, 2.45) correlated with incrementally increasing HCC risk (p<0.001), compared with ALT normalization at 6 months, irrespective of fatty liver or cirrhosis at baseline and VR during treatment.

On the other hand, neither VR (AHR, 0.93; p=0.53) nor earlier hepatitis B e antigen seroclearance (AHR, 0.91; p=0.31) correlated with a significantly reduced HCC risk.

“It was suggested that normalization of serum ALT levels at 1 year of antiviral treatment is associated with a lower risk of hepatic events in patients with CHB,” the investigators noted.

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Most Read Articles
06 Jun 2019
Treatment with probiotics falls short of improving gastrointestinal (GI) symptoms in patients with systemic sclerosis, a study has shown.
11 May 2020
A number of patients with coronavirus disease 2019 (COVID-19) present with diarrhoea, and this group may suffer discomfort longer and show persistent positive SARS-CoV-2 in stool specimens as compared with patients who do not have the symptom, as shown in a study.
Stephen Padilla, 28 Oct 2019
Any manner of early postoperative diet delivered into the gastrointestinal tract (GIT) following colorectal surgery will help stimulate gut motility, leading to an earlier return of bowel function and a shorter length of hospital stay (LOS), according to a systematic review and meta-analysis.
11 May 2020
Antireflux surgery results in improved quality of life (QOL) and reduced oesophageal acid exposure in neurologically normal (NN) and impaired (NI) children in the short and medium term, according to the results of a systematic review.