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E-cigarette use linked to lower fecundability

31 May 2020

Women who use e-cigarettes appear to have slightly reduced fecundability, although it is unclear whether it represents a causal effect, a study has reported.

Researchers looked at a cohort of 4,586 women aged 21–45 years who were enrolled in Pregnancy Study Online (PRESTO), a web-based prospective preconception study. All women reported current and former e-cigarette use and completed bimonthly follow-up questionnaires until self-reported pregnancy or censoring.

The population contributed 14,489 menstrual cycles of attempt time and 2,604 pregnancies. At baseline, 609 women reported having used an e-cigarette, and 172 were current users.

Proportional probabilities models controlled for potential confounders showed that relative to never use, current e-cigarette use was associated with slightly lower fecundability (fecundability ratio [FR], 0.84, 95 percent confidence interval [CI], 0.67–1.06).

Compared with current nonusers of e-cigarettes and combustible cigarettes, current dual-users of e-cigarettes and cigarettes had an FR of 0.83 (95 percent CI, 0.54–1.29), current e-cigarette users who were non-smokers had an FR of 0.91 (95 percent CI, 0.70–1.18), and cigarette smokers who were not e-cigarette users had an FR of 1.01 (95 percent CI, 0.85–1.20).

Fecundability estimates of the independent and joint associations of e-cigarette use with combustible cigarette smoking were inconsistent and imprecise, according to the researchers.

Nevertheless, women planning a pregnancy, especially smokers who wish to cut or substitute combustible cigarette exposure, may seek guidance on the safety of using e-cigarettes during the preconception period, they added.

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Most Read Articles
Roshini Claire Anthony, 5 days ago

Children who are fully vaccinated against the flu, ie, receive the recommended number of influenza vaccine doses, have a lower risk of acquiring influenza compared with those who are partially vaccinated, a US study found.

06 Jul 2020
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Yesterday
Treatment with levothyroxine appears to have no significant impact on systolic and diastolic heart function in older adults with mild subclinical hypothyroidism as compared with placebo, results of a study have shown.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.