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Dysuria provides clinical hint of urinary tract infection in women

04 Oct 2017

Dysuria signals the presence of urinary tract infection (UTI) better than urinary frequency or urgency or both in women seeking urogynaecologic care, a study suggests.

The study included 150 female patients (mean age 62.3 years; mean body mass index, 29.3 kg/m2) who completed the validated UTI Symptom Assessment questionnaire. Transurethral catheterized urine samples were examined for UTI, the primary outcome measure.

UTI diagnosis was defined in three ways: a nonculture-based UTI diagnosis (self-report) and culture-based UTI diagnoses, including standard urine culture (≥104 colony-forming units [CFU]/mL) and enhanced quantitative urine culture (≥10 CFU/mL) of any uropathogen.

Results showed that the presence of the urinary symptoms of frequency and urgency differed only to a certain extent between UTI-positive and UTI-negative patients (self-report, p=0.005 and p<0.001, respectively; standard urine culture, p=0.038 and p=0.044; enhanced quantitative urine culture, p=0.059 and p=0.098).

On the other hand, the presence of dysuria (pain or burning) during urination was markedly more common among UTI-positive patients for all UTI definitions (self-report, p<0.001; standard urine culture, p<0.001; enhanced quantitative urine culture, p=0.010).

Additionally, compared with patients who did not report dysuria, those who did showed higher severity and bother scores for all other urinary symptoms assessed by the UTI Symptom Assessment questionnaire (frequency, p=0.001; urgency, p=0.006; dysuria, p<0.001).

The present data suggest that the presence of frequency and urgency of urination does not confirm a culture-based UTI diagnosis, researchers said.

“Instead, clinicians can more readily detect UTI using the presence of dysuria, which more effectively discriminates UTI-positive and UTI-negative individuals, regardless of the culture-based method used to diagnose UTI,” they added.

The use of dysuria as a key UTI symptom thus warrants further assessment, researchers said.

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Most Read Articles
Pearl Toh, 10 Jan 2018
A study finds no evidence that using pharmaceutical aids alone for smoking cessation helps improve the chances of successful quitting despite promising results in previous randomized trials and routine prescription of such drugs to help quit smoking.
Elvira Manzano, 6 days ago
Cancer patients at risk for recurrent venous thromboembolism (VTE) are less likely to experience recurrence with rivaroxaban compared with dalteparin, the Select-D trial has shown, ushering in a new standard of care (SoC) for cancer-related VTE.
2 days ago
Rates of immunization particularly in a primary care setting can be improved by constant patient reminders and recall systems, a recent study has found.
Roshini Claire Anthony, 3 days ago

The combination of ceftazidime and avibactam proved noninferior to meropenem in adults with nosocomial pneumonia, positioning it as a potential treatment option for this condition, results from the phase III REPROVE* trial show. Nonetheless, the combination was associated with a higher number of safety events compared with meropenem.