Dysglycaemia associated with future aortic stiffness
Dysglycaemia may lead to future aortic stiffness, according to a recent study. However, aortic stiffness or central blood pressure (BP) is not affected by glycaemic deterioration over 7.8 years independent of other cardiometabolic risk factors.
Using a Danish population-based stepwise screening programme for diabetes, including a diabetes risk score (DRS) questionnaire and glucose measurements, researchers identified seven groups of individuals at increasing levels of diabetes risk.
A total of 2,048 participants underwent aortic stiffness assessment by carotid-femoral pulse wave velocity (aPWV) and assessment of central BP after 7.8 years of follow-up.
The authors compared differences in central haemodynamics at follow-up between the diabetes risk groups and analysed the impact of glycated haemoglobin A (HbA1c) at screening and HbA1c change on central haemodynamics following adjustments for relevant confounders.
The median age and HbA1c at baseline were 59.0 years and 5.7 percent, respectively. At follow-up, median aPWV was 8.0 m/s and median central systolic (S)BP was 123.5 mm Hg.
Central SBP and diastolic (D)BP, aPWV, and pulse pressure were greater in participants with impaired glucose tolerance than those with normal glucose tolerance among individuals with high DRS.
For every 1 percent-point higher HbA1c at screening, aPWV was 0.23 m/s (95 percent CI, 0.00 to 0.46) higher and central DBP was 1.35 mm Hg (0.19 to 2.51) lower, while HbA1c change was not associated with any of the central haemodynamics.
The findings suggest that future aortic stiffness is likely among individuals with impaired glucose tolerance, according to researchers.