Most Read Articles
16 May 2018
An association exists between Ramadan fasting and reduced activity and sleeping time, suggests a study, adding that no significant change is seen in resting metabolic rate (RMR) and total energy expenditure (TEE).
Roshini Claire Anthony, Yesterday

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 4 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Jairia Dela Cruz, 5 days ago
Male smokers under the age of 50 years are at risk of developing ischaemic stroke, and this risk increases with the number of cigarettes smoked daily, according to data from the Stroke Prevention in Young Men Study.

Dysglycaemia associated with future aortic stiffness

21 Aug 2017

Dysglycaemia may lead to future aortic stiffness, according to a recent study. However, aortic stiffness or central blood pressure (BP) is not affected by glycaemic deterioration over 7.8 years independent of other cardiometabolic risk factors.

Using a Danish population-based stepwise screening programme for diabetes, including a diabetes risk score (DRS) questionnaire and glucose measurements, researchers identified seven groups of individuals at increasing levels of diabetes risk.

A total of 2,048 participants underwent aortic stiffness assessment by carotid-femoral pulse wave velocity (aPWV) and assessment of central BP after 7.8 years of follow-up.

The authors compared differences in central haemodynamics at follow-up between the diabetes risk groups and analysed the impact of glycated haemoglobin A (HbA1c) at screening and HbA1c change on central haemodynamics following adjustments for relevant confounders.

The median age and HbA1c at baseline were 59.0 years and 5.7 percent, respectively. At follow-up, median aPWV was 8.0 m/s and median central systolic (S)BP was 123.5 mm Hg.

Central SBP and diastolic (D)BP, aPWV, and pulse pressure were greater in participants with impaired glucose tolerance than those with normal glucose tolerance among individuals with high DRS.

For every 1 percent-point higher HbA1c at screening, aPWV was 0.23 m/s (95 percent CI, 0.00 to 0.46) higher and central DBP was 1.35 mm Hg (0.19 to 2.51) lower, while HbA1c change was not associated with any of the central haemodynamics.

The findings suggest that future aortic stiffness is likely among individuals with impaired glucose tolerance, according to researchers.

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Most Read Articles
16 May 2018
An association exists between Ramadan fasting and reduced activity and sleeping time, suggests a study, adding that no significant change is seen in resting metabolic rate (RMR) and total energy expenditure (TEE).
Roshini Claire Anthony, Yesterday

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 4 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Jairia Dela Cruz, 5 days ago
Male smokers under the age of 50 years are at risk of developing ischaemic stroke, and this risk increases with the number of cigarettes smoked daily, according to data from the Stroke Prevention in Young Men Study.