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Dupilumab safe, effective for atopic dermatitis

06 May 2018
Childhood atopic dermatitis or eczema takes a heavy toll not just physically and emotionally, but financially as well

Dupilumab, at dose regimens of 300 mg once weekly (qw) or once every 2 weeks (q2w), is effective and safe for atopic dermatitis, a recent meta-analysis has shown.

Pooled analysis of six trials (n=2,447) revealed that there was a significant decrease in the Eczema Area and Severity Index (EASI) scores following dupilumab treatment (standardized mean difference [SMD], –0.89; 94 percent CI, –1.00 to –0.78; p<0.00001).

The effect remained significant in both the 300 mg qw (SMD, –0.93; –1.10 to –0.76; p<0.00001) and q2w (SMD, –0.86; –1.02 to –0.71; p<0.00001) dosing regimens.

Dupilumab was better than placebo even when using other efficacy measures: percentage of body surface area (SMD, –0.83; –0.90 to –0.75; p<0.00001), Investigators Global Assessment response (risk ratio [RR], 3.82; 3.23–4.51; p<0.00001), pruritus numeric rating scale score (SMD, –0.81; –0.96 to –0.66; p<0.00001) and Dermatology Life Quality Index (SMD, –0.78; –0.89 to –0.66; p<0.00001).

In all cases above, both dosing regimens were significantly effective.

While all trials reported adverse events, the overall rates were statistically similar between dupilumab and placebo (42 percent vs 43 percent; RR, 1.0; 0.96–1.04; p=0.83). The rates of patients with ≥1 adverse event for the 300-mg qw and q2w dosing regimens were 32.8 percent (RR, 0.99; 0.94–1.05; p=0.81) and 41.9 percent (RR, 1.0; 0.94–1.06; p=0.97), respectively.

Accessing the databases of CBM, the Cochrane Library, Embase and PubMed, researchers identified randomized controlled trials of dupilumab treatment on adult atopic dermatitis patients. Observational, case-control and nonblinded studies were excluded from the meta-analysis.

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Most Read Articles
2 days ago
The types of bariatric surgery differentially affect the risk of developing acute pancreatitis postoperatively, such that the risk is greater in patients who undergo vertical sleeve gastrectomy vs Roux-en-Y gastric bypass surgery, according to a study. Risk factors include younger age and presence of gallstones.
6 days ago
Elderly adults using hypoglycaemic glucose-lowering drugs, such as insulin and glinides, have an excess risk of hospitalization for serious trauma, a recent study has found.
6 days ago
Rather than the presence or type or urinary incontinence, increasing severity of urinary incontinence correlates with increased depression, anxiety and stress among treatment-seeking women with lower urinary tract symptoms (LUTS), suggests a study.
Roshini Claire Anthony, 4 days ago

Overweight or obese patients taking lorcaserin as an appetite suppressant may have the added benefit of a reduced risk of incident diabetes, according to results of the CAMELLIA-TIMI 61* trial presented at EASD 2018.