Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Natalia Reoutova, 07 Jan 2020

A prospective cohort study of mothers taking antiepileptic drugs (AEDs) and their breastfed infants has found substantially lower AED concentrations in infant vs maternal blood, with nearly half of all obtained AED concentrations in nursing infants being less than the lower limit of quantification (LLoQ).

5 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.

Dupilumab, cyclosporine proven safe, effective for severe atopic dermatitis

27 Jan 2019

Current evidence shows dupilumab and cyclosporine as effective treatment for severe atopic dermatitis (AD), reports a recent systematic review, adding that long-term safety and efficacy of biologic medications require further research.

Forty-one studies met the eligibility criteria and were included in the final analysis. Evidence showed consistent improvements with dupilumab and cyclosporine in Eczema Area and Severity Index and Scoring Atopic Dermatitis.

Lebrikizumab and tralokinumab showed efficacy in phase II clinical trials; phase III trials were thus warranted. Furthermore, there were no studies that reported on the efficacy of such biologic medications in paediatric patients, but cyclosporine improved clinical severity by the greatest amount in this population.

An earlier study reported the efficacy and safety of dupilumab for the treatment of moderate-to-severe AD in adults, supporting its role as a primary targeted biologic medication in adult patients with moderate-to-severe AD. [Oncotarget 2017;8:108480-108491]

Another study suggested that dupilumab is “currently the only biologic [treatment] with robust evidence of efficacy in AD. Other medications (eg, nemolizumab, lebrikizumab and tralokinumab) are promising but require further data. [Am J Clin Dermatol 2018;19:145-165]

The current systematic review accessed Medline, Ovid and Embase databases to compare efficacies of systemic therapies for the treatment of AD. Included were randomized controlled trials that analysed the efficacy of systemic treatments for AD in adults and children.

The study was limited by its lack of well controlled comparison studies that made direct comparisons between treatments difficult.

“Systemic medications are often required for severe AD refractory to topical therapies. Biologic medications are a recent advancement in the field and a comparison with standard systemic approaches would be beneficial,” the authors said.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Natalia Reoutova, 07 Jan 2020

A prospective cohort study of mothers taking antiepileptic drugs (AEDs) and their breastfed infants has found substantially lower AED concentrations in infant vs maternal blood, with nearly half of all obtained AED concentrations in nursing infants being less than the lower limit of quantification (LLoQ).

5 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.