Most Read Articles
18 Sep 2019
Mortality, length of stay (LOS) and hospital charges are significantly higher in chronic liver disease (CLD) patients with fractures, a recent study has shown. These findings are also associated with increased infection, bleeding and poorer wound healing.
01 Aug 2017
New drug applications approved by US FDA as of 16 - 30 June 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Roshini Claire Anthony, 04 Oct 2017

Using a reduced computed tomography (CT) dose to diagnose appendicitis in adolescents and young adults does not appear to affect clinical outcomes, and could potentially reduce the long-term risk of radiation-related cancers, according to results of the LOCAT* trial. 

22 Sep 2019
Oral supplementation with the gut commensal bacterium Akkermansia muciniphila safely improves several metabolic parameters in overweight or obese adults, as shown in a proof-of-concept study.

Duodenal eosinophilia poses heightened risk of GERD in individuals with FD, PDS

25 Jun 2019

Duodenal eosinophilia carries up to a sixfold increased risk of developing gastro-oesophageal reflux disease (GERD) over 10 years in individuals with functional dyspepsia (FD) and postprandial distress syndrome (PDS), a study has found.

Researchers randomly selected 1,000 adults for an oesophagogastroduodenoscopy and a more comprehensive abdominal symptom questionnaire and medical history, among whom 703 (mean age, 63.2 years; 51.9 percent female) attended the follow-up evaluation after 10 years. A case‐control study on all available FD patients with histological evaluation of the duodenum at baseline (n=89) vs healthy controls (n=124) was also conducted.

Concomitant GERD symptoms (with no oesophagitis or other organic disease at baseline) presented in 54 FD patients at baseline. On the other hand, 68 individuals reported any GERD symptoms at follow‐up (overlap in 44), of whom 24 had developed new-onset GERD.

On logistic regression analysis, the risk of developing GERD at follow-up was significantly high in patients with FD (odds ratio [OR], 7.6, 95 percent CI, 2.93–19.4; p<0.001) or PDS (OR, 9.0, 3.36–24.0; p<0.001) at baseline. Eosinophilia in the second part of duodenum only showed an independent association with an elevated risk of new-onset GERD among patients with baseline FD (OR, 4.2, 1.2–4.77; p=0.024) or PDS (OR, 6.0, 1.50–23.6; p=0.011).

The present data suggest that duodenal eosinophilia may explain the link between GERD and FD via impaired gastric accommodation and increased transient lower oesophageal sphincter relaxations, the researchers pointed out. The study also supports the concept of FD and GERD being part of the same disease spectrum.

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Most Read Articles
18 Sep 2019
Mortality, length of stay (LOS) and hospital charges are significantly higher in chronic liver disease (CLD) patients with fractures, a recent study has shown. These findings are also associated with increased infection, bleeding and poorer wound healing.
01 Aug 2017
New drug applications approved by US FDA as of 16 - 30 June 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Roshini Claire Anthony, 04 Oct 2017

Using a reduced computed tomography (CT) dose to diagnose appendicitis in adolescents and young adults does not appear to affect clinical outcomes, and could potentially reduce the long-term risk of radiation-related cancers, according to results of the LOCAT* trial. 

22 Sep 2019
Oral supplementation with the gut commensal bacterium Akkermansia muciniphila safely improves several metabolic parameters in overweight or obese adults, as shown in a proof-of-concept study.