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Duloxetine relieves pain in patients with chronic low back pain

10 Apr 2019

Treatment with duloxetine significantly reduces pain over 52 weeks in patients with chronic low back pain without new safety concerns, according to the results of a phase III trial.

The open-label phase III study included 150 patients (mean age 56.4 years; 53.3 percent female; mean weight, 62.6 kg) treated with 60-mg duloxetine once daily for 52 weeks.

Safety was evaluated based on adverse events (AEs), vital signs, laboratory test values, electrocardiogram, Columbia-Suicide Severity Rating Scale and occurrence of falls. Efficacy measures included the Brief Pain Inventory (BPI; average pain, worst pain, least pain and pain right now), BPI Interference, Patient’s Global Impression of Improvement (PGI-I), Clinical Global Impressions of Severity (CGI-S), Roland-Morris Disability Questionnaire–24 (RDQ-24), 36-Item Short-Form Health Survey (SF-36) and European Quality of Life-5 Dimensions Questionnaire (EQ-5D).

The incidence rate of AEs and adverse drug reactions (ADRs) were 86.1 percent and 50.3 percent, respectively. ADRs occurring in ≥5-percent of patients were somnolence, constipation, nausea and dry mouth. AEs led to treatment discontinuation in 16 patients.

In terms of efficacy, BPI average pain score significantly decreased from baseline at all time points: from week 2 (mean change, −1.02) to week 50 (mean change, −2.2). There were also improvements seen in BPI pain severity (worst pain, least pain and pain right now), BPI Interference, PGI-I, CGI-S, RDQ-24, SF-36 and EQ-5D.

The present data indicate that duloxetine is useful in the long-term treatment of patients with chronic low back pain, researchers said.

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Most Read Articles
6 days ago
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
Stephen Padilla, 13 Feb 2020
A pharmacist intervention appears to be effective in lowering and preventing the incidence of prescribing errors of investigational drugs in oncology clinical trials, a recent study has shown.