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Rachel Soon, 03 Apr 2019

The Malaysian Community Pharmacy Guild (MCPG) has submitted a seven-point proposal for comprehensively including community pharmacists (CPs) in the national healthcare system.

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Rachel Soon, 24 Apr 2019

With recent recalls of losartan-containing products contaminated by potentially carcinogenic nitrosamines, MIMS speaks to the Malaysian National Pharmaceutical Regulatory Agency (NPRA) for more details.

Rachel Soon, 22 hours ago

Many patient-facing healthcare professionals are supported by colleagues in the back room who make sure they stay well-supplied. For its May-June 2019 issue, MIMS Pharmacist speaks to Choong Kin Hoe, former logistics pharmacist at Hospital Kuala Lumpur (HKL), about what goes on in the store pharmacy.

Dual inhibition of EGFR, HER3 confers no survival benefit in metastatic colorectal cancer

10 Jun 2018

The dual-action antibody directed against epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 3 (HER3), duligotuzumab, does not appear to provide survival advantage compared with cetuximab in patients with RAS exon 2/3 wild-type metastatic colorectal cancer (mCRC) treated with the FOLFIRI (folinic acid, fluorouracil and irinotecan) regimen, according to the results of a phase II trial.

A total of 134 mCRC patients (median age 62 years; 61 percent male) with KRAS exon 2 wild-type were randomized to receive either duligotuzumab (n=68) or cetuximab (n=66) with FOLFIRI until progression or intolerable toxicity. Researchers performed mutation and biomarker analysis on mandatory tumour samples, as well as efficacy analysis in patients with RAS exon 2/3 wild-type tumours.

Of the patients, 98 had RAS exon 2/3 wild-type tumour, with 53 in the duligotuzumab arm and 45 in the cetuximab arm.

Efficacy data revealed that in the subgroup of patients with RAS wild-type tumours, duligotuzumab did not improve progression-free survival (median PFS, 7.3 vs 5.7 months; stratified hazard ratio [HR], 1.21; 90 percent CI, 0.81–1.81) or overall survival (median OS, 14.0 vs 13.1 months; stratified HR, 1.00; 0.61–1.66) compared with cetuximab. Moreover, a trend toward a lower objective response rate (ORR) was observed in the duligotuzumab arm (19 percent vs 33 percent; stratified HR, 0.47; 0.21–1.01).

There was no association observed between PFS or ORR and ERBB3, NRG1 or AREG expression. In terms of safety, duligotuzumab was associated with fewer skin rash events but more diarrhoea. Additionally, although the incidence of grade ≥3 adverse events (AEs) was similar between the two treatment arms, the frequency of serious AEs was higher with duligotuzumab.

Further development of duligotuzumab has been discontinued.

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Most Read Articles
Rachel Soon, 03 Apr 2019

The Malaysian Community Pharmacy Guild (MCPG) has submitted a seven-point proposal for comprehensively including community pharmacists (CPs) in the national healthcare system.

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At the recent GLYCEMIC GUARDIANS™ dinner symposium, three eminent speakers spoke on theindispensable role of medical nutrition therapy (MNT) in improving outcomes for patients with type2 diabetes (T2D).
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With recent recalls of losartan-containing products contaminated by potentially carcinogenic nitrosamines, MIMS speaks to the Malaysian National Pharmaceutical Regulatory Agency (NPRA) for more details.

Rachel Soon, 22 hours ago

Many patient-facing healthcare professionals are supported by colleagues in the back room who make sure they stay well-supplied. For its May-June 2019 issue, MIMS Pharmacist speaks to Choong Kin Hoe, former logistics pharmacist at Hospital Kuala Lumpur (HKL), about what goes on in the store pharmacy.