Most Read Articles
Roshini Claire Anthony, 12 Nov 2018

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 09 Nov 2018
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
14 Nov 2018
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.
3 days ago
Higher exposure to ticagrelor following myocardial infarction does not appear to contribute to an increased risk of intracranial haemorrhage, which is associated with age and prior cardiovascular morbidities, according to a study.

Drugs for urinary incontinence may elevate risk of xerostomia in elderly

01 Nov 2017

Xerostomia and salivary gland hypofunction appear to be common side effects of elderly medication, particularly those for urinary incontinence, according to a recent study.

The research team performed a meta-analysis of 52 eligible papers, of which 33 were experimental studies, 19 were observational and cross-sectional, and six were pooled analyses. For inclusion, studies had to have an elderly sample and include comparator or control groups. Outcomes were xerostomia, hyposalivation or hypofunction of salivary glands.

Analysis of pooled data from 22 placebo-controlled randomized controlled trials revealed a statistically significant relationship between xerostomia and urological medications (odds ratio [OR], 5.91; 95 percent CI, 4.04 to 8.63; p<0.00001).

When the research team considered specific medications, they found that oxybutynin conferred the highest risk of dry mouth (OR, 18.85; 8.43 to 42.16; p<0.00001) followed by darifenacin (OR, 7.41; 2.87 to 19.15; p<0.0001). Fesoterodine (OR, 6.94; 3.59 to 13.43; p<0.00001) and tolterodine (OR, 4.82; 3.25 to 7.15; p<0.00001) were also significantly associated with a higher risk of dry mouth while mirabegron (OR, 1.17; 0.48 to 2.89; p=0.73) was not.

Antidepressant use was also significantly associated with xerostomia (OR, 4.74; 2.69 to 8.32; p<0.00001), with the specific drug duloxetine (OR, 6.02; 3.42 to 10.60; p<0.00001) having the largest risk. In contrast, escitalopram (OR, 2.19; 0.85 to 5.61; p=0.10) and doxepin (OR, 2.91; 0.30 to 28.31; p=0.36) were not associated with the risk of dry mouth.

Psycholeptics also significantly increased the risk of xerostomia more than placebo (OR, 2.59; 1.70 to 3.95; p<0.00001), with both eszopiclone (OR, 6.10; 1.34 to 27.80; p=0.02) and quetiapine (OR, 2.42; 1.56 to 3.74; p<0.0001) showing statistically significant associations. 

Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 12 Nov 2018

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 09 Nov 2018
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
14 Nov 2018
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.
3 days ago
Higher exposure to ticagrelor following myocardial infarction does not appear to contribute to an increased risk of intracranial haemorrhage, which is associated with age and prior cardiovascular morbidities, according to a study.