Most Read Articles
Roshini Claire Anthony, 3 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

5 days ago
Eating behaviours have been shown to moderate the relationship between cumulated risk factors in the first 1,000 days and adiposity outcomes at 6 years of age, which underscores modifiable behavioural targets for interventions, reports a study.
Stephen Padilla, 4 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Tristan Manalac, 25 May 2020
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.

Drug use ups risk of HCV reinfection

04 Apr 2020

Injecting drugs appears to elevate the risk of hepatitis C virus (HCV) reinfection among those who had already been treated, reports a new meta-analysis.

Accessing the databases of PubMed, Scopus, Web of Science, CENTRAL and PsycINFO, researchers retrieved 36 studies corresponding to 6,331 person-years of follow-up. Thirty-three studies provided information about injecting and noninjecting drugs, 31 had data on injected drugs alone, and 25 studies included patients who had taken opioid agonist therapies (OATs).

HCV reinfection was higher among those with recent drug use. In patients who used injecting and noninjecting drugs, the rate of reinfection was 5.9 per 100 person-years; in those who were injecting users, reinfection occurred at a rate of 6.2 per 100 person-years.

In comparison, those who were taking OATs had a lower HCV reinfection rate, at 3.8 per 100 person-years.

A similar trend was reported for persistent HCV reinfection. Pooled rates from 24 studies were 5.1, 5.4 ad 3.4 per 100 person-years in recent drug users, recent injecting users and those on OAT.

Meta-regression analysis further showed that in patients on OAT, concomitant recent drug use more than tripled the risk of HCV reinfection (adjusted rate ratio [RR], 3.50, 95 percent confidence interval [CI], 1.62–7.53; p=0.002). Notably, the risk was even higher among patients with recent drug use but who were not on OAT (adjusted RR, 3.96, 95 percent CI, 1.82–8.59; p=0.001).

“Monitoring HCV reinfection following successful HCV treatment in people who inject drugs will be crucial to HCV elimination efforts,” the researchers said. “Further studies are required to evaluate innovative strategies and models of care to enhance engagement in post-treatment care and prevent HCV reinfection among people who inject drugs.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 3 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

5 days ago
Eating behaviours have been shown to moderate the relationship between cumulated risk factors in the first 1,000 days and adiposity outcomes at 6 years of age, which underscores modifiable behavioural targets for interventions, reports a study.
Stephen Padilla, 4 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Tristan Manalac, 25 May 2020
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.