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Pearl Toh, 18 Feb 2016
Treatment with eluxadoline, a new oral medication, relieved two major symptoms of irritable bowel syndrome with diarrhoea (IBS-D) — abdominal pain and diarrhoea, according to a study based on two phase III randomized controlled trials. [N Engl J Med 2016;374:242-253]
Su Ping Chuah, 01 Aug 2014

The Lancet has launched a special series issue that highlights the global HIV epidemic among sex workers, a key but overlooked population for HIV prevention. The series – launched at the 20th International AIDS conference in Melbourne – consists of seven papers that aim to investigate the complex health issues faced by sex workers worldwide, and calls for the decriminalization of sex work, in the global effort to tackle the HIV/AIDS epidemic. [Available at www.thelancet.com/series/HIV-and-sex-workers. Accessed on 23 July 2014]

01 Apr 2016
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Tristan Manalac, 5 days ago
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Double dose of kisspeptin-54 improves oocyte yield in women at high risk of OHSS

Elaine Soliven
27 Sep 2017

A second dose of kisspeptin-54 improves oocyte yield in women at high risk of ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF) treatment, according to a recent study.

“[A] second dose of kisspeptin-54 is a safe option in patients undergoing IVF treatment to further optimize oocyte maturation, even those at high risk of OHSS,” said the researchers. “Further studies are warranted to directly compare kisspeptin-54 to more established triggers of oocyte maturation.”

Sixty-two women with intact ovaries (aged 18–34 years, median body mass index 18–29 kg/m2) undergoing a single IVF cycle received kisspeptin-54 (9.6 nmol/kg) injected subcutaneously at 36 hours prior to oocyte retrieval. Patients were randomized in a 1:1 ratio to a single dose or double dose of kisspeptin-54, the latter administered 10 hours after the first dose to trigger oocyte maturation.

More women in the double-dose group achieved an oocyte yield of ≥60 percent than those in the single-dose group (71 percent [n=22] vs 45.2 percent [n=14]; difference, 25.8 percent, 95 percent confidence interval, 2.1–49.5 percent; p=0.042). [Hum Reprod 2017;32:1915-1924]

Implantation rates were significantly higher in women who received a double dose of kisspeptin-54 than a single dose (37 percent vs 23.3 percent). Live birth rates were also higher with double dose vs single dose of kisspeptin-54 (39 percent vs 19.4 percent).

The oocyte maturation rate was 82 percent for both treatment groups, where all patients in the double-dose group had at least one mature oocyte that was retrieved and fertilized to form an embryo for transfer.

One woman in the single-dose group had an unexplained miscarriage during the second trimester of pregnancy (19 weeks of gestation).

There was no difference in the incidence of OHSS between the two groups. One woman in the single-dose group was diagnosed with moderate, early OHSS, and one woman in the double-dose group had mild, late OHSS.

“Despite the study population being at high risk of developing OHSS, a second dose of kisspeptin-54 did not increase the occurrence of excessive ovarian response or OHSS,” noted the researchers.
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Most Read Articles
Pearl Toh, 18 Feb 2016
Treatment with eluxadoline, a new oral medication, relieved two major symptoms of irritable bowel syndrome with diarrhoea (IBS-D) — abdominal pain and diarrhoea, according to a study based on two phase III randomized controlled trials. [N Engl J Med 2016;374:242-253]
Su Ping Chuah, 01 Aug 2014

The Lancet has launched a special series issue that highlights the global HIV epidemic among sex workers, a key but overlooked population for HIV prevention. The series – launched at the 20th International AIDS conference in Melbourne – consists of seven papers that aim to investigate the complex health issues faced by sex workers worldwide, and calls for the decriminalization of sex work, in the global effort to tackle the HIV/AIDS epidemic. [Available at www.thelancet.com/series/HIV-and-sex-workers. Accessed on 23 July 2014]

01 Apr 2016
Amiodarone is safe and effective for early junctional ectopic tachycardia prophylaxis in paediatric patients following open heart surgery, based on a study.
Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.