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Does antioxidants supplementation improve pancreatic functions in chronic pancreatitis?

14 Feb 2020

Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.

“AO supplementation in chronic pancreatitis has been evaluated for pain, [b]ut it is not clear whether AO in chronic pancreatitis has an effect on pancreatic functions and other clinical outcomes,” the investigators said.

To evaluate the effect of AO on endocrine function, a double-blind placebo-controlled randomized pilot study was conducted. A total of 107 patients with chronic pancreatitis were randomly assigned to receive either daily combined AO or placebo for 6 months. Improvement in endocrine function, using the Homeostasis Model Assessment-Insulin Resistance, was the primary outcome.

Secondary outcomes were as follows: improvement in C-peptide, Quality Insulin Sensitivity Check Index, exocrine pancreatic function (faecal elastase), surrogate markers of fibrosis (platelet-derived growth factor BB, transforming growth factor-β1, α-smooth muscle actin), QOL, pain, nutritional status, markers of OS, AO status and inflammation.

Patients in the AO group, compared with those on placebo, had an increase in levels of serum selenium (107.2±26.9 to 109.7±26.9 vs 104.1±28.6 to 124.0±33.6 μg/L; p=0.022) and serum vitamin E (0.58 to 0.66 vs 0.63 to 1.09 mg/dL; p=0.001). There were no significant between-group differences seen in any of the primary or secondary outcome measures.

“Further larger studies with adequate sample size are required,” the investigators said.

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Most Read Articles
3 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 2 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
01 Apr 2020
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
2 days ago
Cuff-based excess pressure (XSP) is modestly associated with carotid intima–media thickness independent of conventional risk factors, reveals a recent study.