Most Read Articles
Jairia Dela Cruz, 05 Oct 2020
Drinking more than two cups of coffee per day may just be the intervention that prevents hundreds of thousands of liver disease‐related deaths globally, a study reports.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

Stephen Padilla, Yesterday
Use of systemic corticosteroids does not reduce in-hospital mortality for patients with severe or critical coronavirus disease (COVID-19), which is in stark contrast to that observed in the RECOVERY clinical trial, according to a study in Wuhan, China.

Doctor’s judgement falls short for assessing frailty in elderly cancer patients

27 Sep 2020

The physician’s clinical judgement is insufficient for the assessment of frailty among elderly cancer patients, and should be complemented with more structured tools, such as the geriatric assessment (GA), a recent study has found

The study included 55 cancer patients (aged ≥70 years; 40 percent female) who were just initiating curative or first-line palliative chemotherapy. Physicians were asked to judge patient frailty using a rating scale that ranged from 0–10, with 10 indicating frailty. Participants were also evaluated using the GA, which included the mood, polypharmacy, mobility, nutrition, and instrumental activities of daily living (IADL) domains.

The GA saw a high prevalence of geriatric impairments. For example, 75 percent were at risk of malnutrition and 60 percent had impaired IADL. Overall, each participant showed a median of two impairments, though 49 percent had three or more impairments.

In contrast, clinical assessors deemed that the patients were relatively fit, and the resulting median frailty score for all three assessors was 3. There was a weak and positive correlation between the assessors, but for individual patients, the variations between each judge’s scores were large.

In turn, the associations between clinical judgement scores and GA findings were also weak and positive, such that as the number of GA impairments increased, the assessors also tended to assign higher rating scale values. However, clinical judgement remained too conservative. Patients with ≥3 impaired domains would still get scored <5 on the clinical frailty rating scale.

“[O]ther frailty assessments, such as frailty screening tools or GA, should be considered in addition to clinical judgment when selecting older patients with cancer for potential treatment with chemotherapy,” researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Jairia Dela Cruz, 05 Oct 2020
Drinking more than two cups of coffee per day may just be the intervention that prevents hundreds of thousands of liver disease‐related deaths globally, a study reports.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

Stephen Padilla, Yesterday
Use of systemic corticosteroids does not reduce in-hospital mortality for patients with severe or critical coronavirus disease (COVID-19), which is in stark contrast to that observed in the RECOVERY clinical trial, according to a study in Wuhan, China.