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Diurnal BP loads linked to lower cognitive performances in CHT individuals

Stephen Padilla
16 Oct 2019
tDCS is not approved by the U.S. FDA, and scientists have differing views on its efficacy.

Diurnal blood pressure (BP) loads appear to lower cognitive function in individuals with controlled hypertension (CHT), suggests a recent study.

Lower cognitive performances were observed on immediate and delayed recall and total number of words of the Rey Auditory Verbal Learning Test (p<0.001) in the analysis of covariance between normotensive and CHT participants.

In Spearman’s correlations between BP loads and cognitive performances, inverse association were found between diurnal systolic (SBP) loads and performances on the Trail Making Test (TMT) Part B (p=0.009), the TMT Part B–Part A (p=0.013), the Switching Cost of the color-word interference test (p=0.020) and the Digit-Symbol Substitution Score tests (p=0.018) in CHT.

Diurnal diastolic loads were inversely associated with the TMT Part B (p=0.014) and TMT Part B–Part A (p=0.006). In addition, diurnal SBP loads in normotensive individuals correlated with the delayed recall of the Rey Auditory Verbal Learning Test (p=0.031) and the three components of the digit span (p<0.05).

“These results suggest a lowering of target levels of diurnal BPs and/or its variability,” the authors said.

Individuals aged between 60 and 75 years were divided into normotensive participants who did not receive antihypertensive therapy (n=49) and CHT patients (n=28). They were assessed for BP using ambulatory BP monitoring and for cognitive functions using tests evaluating cognitive flexibility, working and episodic memory, and processing speed.

“Hypertension in midlife adults is associated with cognitive decline later in life,” the authors said. “In individuals treated for hypertension, BP loads have been associated with end organ damages.”

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Most Read Articles
Jairia Dela Cruz, 3 days ago
Metabolic and bariatric surgery (MBS) leads to large and sustained reductions in, and even reversal of, multiple risk factors for future joint disease in adolescents with severe obesity and musculoskeletal pain, according to data from the Teen Longitudinal Assessment of Bariatric Surgery study.
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 6 days ago
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.