Most Read Articles
Elaine Soliven, 5 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

3 days ago
Among individuals with abdominal obesity, drinking beverages with artificial sweeteners (ASBs) or no sugar (USBs) instead of sugar-sweetened beverages (SSBs) helps lose body weight, a study has found. However, USBs have a more favourable effect on sweet taste preference compared with ASBs.
Stephen Padilla, 5 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 4 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.

Disease stage predicts survival in Wilms tumour in developing countries

27 Jun 2020

Disease stage is the most important prognostic factor of Wilms tumour (WT) in developing countries, a recent study has found.

Researchers retrospectively analysed 84 WT patients (mean age, 38.87±28.66 months; 52.4 percent female) receiving care at a military hospital in Pakistan. Treatments were given according to the guidelines of the International Society of Paediatric Oncology.

There were four treatment-related mortalities, yielding an incidence rate of 4.8 percent. These included two cases of sinusoidal obstruction syndrome, one of Fanconi anaemia with metastatic disease, and one death during surgery. Seventeen patients relapsed, only three of whom were successfully rescued; the remaining 14 died of progressive disease.

The resulting overall survival (OS) rate was 78.6 percent (n=66), while the event-free survival (EFS) rate was 75 percent (n=63).

Multivariate logistic regression analysis showed that advanced disease stage was the strongest predictor of both OS (p=0.003) and EFS (p=0.021). For instance, OS was only 50.0 percent in patients with stage V disease, as opposed to 47.1 percent, 69.2 percent, 92.0 percent and 92.6 percent in those with stage IV, III, II, and I WT.

EFS, in comparison, was lowest in patients with stage IV WT (43.8 percent), followed by stage V (50.0 percent), stage III (69.2 percent), stage II (79.2 percent), and stage I (92.6 percent).

Metastatic disease likewise worsened outcomes. Both OS and EFS were 0 percent in patients who developed both pulmonary and hepatic metastases.  

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS JPOG - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Elaine Soliven, 5 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

3 days ago
Among individuals with abdominal obesity, drinking beverages with artificial sweeteners (ASBs) or no sugar (USBs) instead of sugar-sweetened beverages (SSBs) helps lose body weight, a study has found. However, USBs have a more favourable effect on sweet taste preference compared with ASBs.
Stephen Padilla, 5 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 4 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.