Most Read Articles
6 days ago
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

3 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
Pearl Toh, 3 days ago
Drinking more water did not significantly slow down the decline in kidney function of patients with stage 3 chronic kidney disease (CKD) at 1 year compared with patients who maintained their daily water intake, the CKD WIT* randomized study suggests.

Disease duration in AxSpA ups risk of acute anterior uveitis, inflammatory bowel disease

04 Jun 2018

The risk of developing acute anterior uveitis or inflammatory bowel disease (IBD), but not psoriasis, appears to increase with disease duration in axial spondyloarthritis (AxSpA), and this risk is associated with higher cumulative exposure to inflammation, as reported in a study.

The study drew data from the (Be)Giant cohort, which included consecutive patients with AxSpA since 2010, and the ASPECT cohort, which provided information on consecutive patients with ankylosing spondylitis (AS) and probable AS.

A total of 1,250 Belgian AxSpA patients were included in the analysis: 928 patients who fulfilled the New York modified criteria for AS (847 ASPECT; 81 (Be)GIANT) and 322 nonradiographic-AxSpA patients (176 ASPECT; 146 [Be]Giant).

In multiple logistic regression models, disease duration in AxSpA was associated with acute anterior uveitis and IBD risks. Specifically, 10-year disease duration was associated with a 20-percent increase in the risk of acute anterior uveitis (relative risk [RR], 1.2; p<0.001) and a 30-percent increase in the risk of IBD (RR, 1.3; p=0.026).

In a subgroup of 171 newly diagnosed AxSpA patients, those with acute anterior uveitis or IBD exhibited higher mean C-reactive protein (CRP) levels over time compared with those who did not have extra-articular manifestations (EAMs) or who had psoriasis alone (p=0.01).

Researchers warned that the present data, although indicative of an association between the presence of certain EAMs and CRP, do not necessarily represent a causal relationship. It is possible that the appearance of IBD or acute anterior uveitis may just as well be an expression of cumulative exposure to systemic inflammation.

Rather, the data support the hypothesis that the overall exposure to systemic inflammation varies according to the spectrum of EAM in AxSpA, potentially involving a higher risk of structural progression in patients with IBD and/or acute anterior uveitis vs psoriasis. Researchers pointed out that because such EAMs appear to occur early and prior to diagnosis, they may be an early indication of progressive disease risk.

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Most Read Articles
6 days ago
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

3 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
Pearl Toh, 3 days ago
Drinking more water did not significantly slow down the decline in kidney function of patients with stage 3 chronic kidney disease (CKD) at 1 year compared with patients who maintained their daily water intake, the CKD WIT* randomized study suggests.