Most Read Articles
Rachel Soon, 3 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

16 Mar 2019
Sleep difficulties are exacerbated in long-term survivors of childhood cancers, which may lead to persistent emotional distress, a new study has found.
2 days ago
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 5 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.

Direct-acting antivirals do not raise HCC risk in hepatitis C patients

22 Jul 2018
Authorities in Malaysia have approved a compulsory license for Hepatitis C treatment, which allows for cheaper generic medication to be produced without the drug patent holder’s consent.

In patients with advanced hepatitis C infections, taking direct-acting antivirals (DAAs) does not increase the risk of subsequent hepatocellular carcinoma (HCC), a recent study has shown.

Researchers conducted a prospective study of 3,917 patients with hepatitis C infection who were taking DAAs (mean age 58.1±11.9 years; 62.2 percent male); only those with fibrosis stage F3 were eligible for inclusion. Cox regression analyses were performed to identify risk factors for HCC development.

Over a mean follow-up of 536.2±197.6 days, 55 new cases of HCC were reported, yielding an overall incidence rate of 0.97 percent patients per year. The corresponding incidence rate in cirrhotic patients was 1.18 percent patients per year.

Multivariate analysis of baseline variables showed that coinfection with hepatitis B virus (hazard ratio [HR], 3.99; 95 percent CI, 1.24–12.91; p=0.021) and APRI (aspartate aminotransferase-to-platelet ratio) score >2.5 (HR, 2.03; 1.14–3.61; p=0.016) were significant and independent risk factors for HCC development.

In 55 patients who developed HCC (mean age 59.15±9.7 years; 37 males), all hepatitis C virus genotypes were present. The time from DAA initiation to HCC diagnosis ranged from 4–57 weeks and averaged 31.8±20.1 weeks. Twenty-two patients developed HCC while on DAA medication.

In relation to virological outcomes, those who experienced sustained virological response (SVR) were less likely to contract the aggressive form of HCC than in those without SVR (54.6 percent vs 12.1 percent). Moreover, the aggressive HCC pattern was more common during the early periods of observation, while the less aggressive form predominated during later follow-ups.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Rachel Soon, 3 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

16 Mar 2019
Sleep difficulties are exacerbated in long-term survivors of childhood cancers, which may lead to persistent emotional distress, a new study has found.
2 days ago
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 5 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.