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Direct-acting antivirals do not accelerate recurrence of hepatitis C-related HCC

23 Dec 2018

Using direct-acting antivirals (DAA) in treating chronic hepatitis C does not seem to accelerate the recurrence of hepatitis C-related hepatocellular carcinoma (HCC) after curative therapy, a new study has shown.

The study included 147 patients (median age 74.4 years; 59 percent male) successfully treated with radiofrequency ablation for hepatitis C- related HCC and who received antiviral treatment with DAAs. A comparison group of 156 patients (median age 65.3 years; 75 percent male) treated with interferon (IFN)-based therapy was also included.

Over a median observation period of 1.8 years, 80 patients in the DAA group developed HCC recurrence. The resulting 1- and 2-year tumour recurrence rates were 39 percent and 60 percent, respectively. In comparison, 136 recurrence events were recorded over 7.2 observation years in the IFN group, resulting in 1- and 2-year recurrence rates of 39 percent and 61 percent, respectively (p=0.43).

Recurrence patterns did not significantly differ between the DAA and IFN groups (chi-squared test p=0.70). For instance, intrahepatic recurrence of up to three tumours <3 cm in diameter occurred in 85 percent and 84 percent of the IFN- and DAA-treated patients, respectively.

Moreover, extrahepatic metastases were recorded in one patient who received IFN treatment and in two who were given DAAs.

Multivariate Cox proportional hazard regression analysis identified a larger number of HCC treatments and a shorter time between the last HCC treatment and initiation of antiviral therapy as independent risk factors for HCC recurrence.

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Most Read Articles
5 days ago
In patients with type 2 diabetes, obesity may be protective against vision-threatening diabetic retinopathy, a recent Korea study has shown.
Roshini Claire Anthony, 4 days ago

Men with metastatic hormone-sensitive prostate cancer (mHSPC) who receive testosterone suppression therapy may have a better survival outcome with the addition of enzalutamide over other non-steroidal anti-androgen (NSAA) therapies, according to the phase III ENZAMET* trial.

07 Jun 2019
Low-dose aspirin therapy does not confer significant benefits to elderly patients with hypertension, but treatment appears to increase the risk of haemorrhagic events, suggest a Japan study.
4 days ago
The use of opioids may have limited long-term efficacy in the management of chronic noncancer pain, reports a new study.