Most Read Articles
Rachel Soon, 3 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

16 Mar 2019
Sleep difficulties are exacerbated in long-term survivors of childhood cancers, which may lead to persistent emotional distress, a new study has found.
2 days ago
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 5 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.

Direct-acting antivirals do not accelerate recurrence of hepatitis C-related HCC

23 Dec 2018

Using direct-acting antivirals (DAA) in treating chronic hepatitis C does not seem to accelerate the recurrence of hepatitis C-related hepatocellular carcinoma (HCC) after curative therapy, a new study has shown.

The study included 147 patients (median age 74.4 years; 59 percent male) successfully treated with radiofrequency ablation for hepatitis C- related HCC and who received antiviral treatment with DAAs. A comparison group of 156 patients (median age 65.3 years; 75 percent male) treated with interferon (IFN)-based therapy was also included.

Over a median observation period of 1.8 years, 80 patients in the DAA group developed HCC recurrence. The resulting 1- and 2-year tumour recurrence rates were 39 percent and 60 percent, respectively. In comparison, 136 recurrence events were recorded over 7.2 observation years in the IFN group, resulting in 1- and 2-year recurrence rates of 39 percent and 61 percent, respectively (p=0.43).

Recurrence patterns did not significantly differ between the DAA and IFN groups (chi-squared test p=0.70). For instance, intrahepatic recurrence of up to three tumours <3 cm in diameter occurred in 85 percent and 84 percent of the IFN- and DAA-treated patients, respectively.

Moreover, extrahepatic metastases were recorded in one patient who received IFN treatment and in two who were given DAAs.

Multivariate Cox proportional hazard regression analysis identified a larger number of HCC treatments and a shorter time between the last HCC treatment and initiation of antiviral therapy as independent risk factors for HCC recurrence.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Rachel Soon, 3 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

16 Mar 2019
Sleep difficulties are exacerbated in long-term survivors of childhood cancers, which may lead to persistent emotional distress, a new study has found.
2 days ago
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 5 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.