Most Read Articles
Roshini Claire Anthony, 6 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

6 days ago
Patients with coronary artery disease (CAD) treated in a poor Southeast Asian setting appear to have far too high short-term and medium-term mortality rates, according to a study.
4 days ago
Heeding the advice to eat more vegetables has led to an increase in consumption above the Australian Dietary recommendation of ~375 g/day among overweight participants, a recent study has shown. Tomatoes are a common choice regardless of the time of year, but selections change over time.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.

Dipeptidyl peptidase-4 inhibitors up risk of bullous pemphigoid

28 May 2018

Use of dipeptidyl peptidase-4 inhibitors (DPP4is), particularly vildagliptin, appears to increase the risk for developing bullous pemphigoid (BP), according to a recent study.

“Their use needs to be carefully evaluated, particularly in high-risk patients, such as males and those aged 80 years or older,” the authors said.

A total of 61 patients with diabetes and BP and 122 controls were included in the study. There was an association between DPP4is and an increased risk for BP development (adjusted odds ratio [AOR], 2.64; 95 percent CI, 1.19–5.85; p=0.02), with vildagliptin showing the highest AOR (3.57; 1.07–11.84; p=0.04).

In stratified analysis, a stronger association was seen in males and patients aged 80 years. In addition, DPP4i withdrawal and the initiation of first-line treatments resulted in clinical remission in 95 percent of patients.

These findings support those of a recent case report and literature review, which found that DPP4is may trigger the onset of BP similarly to a thermal burn. Additionally, researchers suggested that the clinical and histopathological features of DPP4i-induced BP may be distinct from other types of BP. [Front Immunol 2018;9:542]

To assess the link between DPP4i treatment and BP development, the authors conducted a retrospective 1:2 case-control study, comparing case patients with diabetes and BP with age- and sex-matched controls with diabetes issued from Swiss and French dermatologic departments from 1 January 2014 and 31 July 2016.

The study was limited by its design and focus on DPP4i intake without analysing the potential isolated effect of metformin, according to the authors.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

6 days ago
Patients with coronary artery disease (CAD) treated in a poor Southeast Asian setting appear to have far too high short-term and medium-term mortality rates, according to a study.
4 days ago
Heeding the advice to eat more vegetables has led to an increase in consumption above the Australian Dietary recommendation of ~375 g/day among overweight participants, a recent study has shown. Tomatoes are a common choice regardless of the time of year, but selections change over time.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.