Diets rich in cottonseed oil improve fasting cholesterol, triglyceride
A high-fat diet rich in cottonseed oil (CSO) appears to effectively improve cholesterol and triglyceride concentrations, a recent study has found. In contrast, olive oil (OO)-rich diets exert no such effects.
Researchers randomly assigned 15 normal-weight men (mean age 21.6±2.58 years; mean body mass index, 24.27±2.81 kg/m2) to receive either CSO-rich or OO-rich diets for 5 days before crossover. Diets were 50-percent fat and blood samples were collected during pre- and postdiet visits.
Fasting levels of total cholesterol dropped from previsit values following the CSO diet (148.40±6.39 to 135.93±6.31 mg/dL; p<0.05). No such effect was observed during the OO-intervention arm (149.71±6.38 vs 140.93±6.92 mg/dL).
Similar effects on fasting low-density lipoprotein cholesterol (LDL-C) levels were observed for the CSO (92.20±5.57 to 78.13±5.60 mg/dL; p<0.05) and OO (91.14±6.87 to 85.64±6.29 mg/dL) interventions. The same was true for fasting triglyceride levels (CSO: 80.11±4.91 to 56.37±5.46 mg/dL; p<0.05; OO: 74.51±8.38 to 64.08±6.87 mg/dL).
In contrast, the CSO diet led to significant increases in the mean fasting high-density lipoprotein cholesterol (HDL-C) levels (46.67±2.41 to 50.24±2.20 mg/dL; p<0.05), while the OO diet remained ineffective (48.92±2.44 to 48.21±1.92 mg/dL).
In terms of between-diet comparisons, researchers found that LDL-C (78.13±5.61 vs 85.64±6.29 mg/dL; p<0.05) and triglyceride (56.37±5.46 vs 64.08± 6.87 mg/dL; p<0.05) concentrations were significantly lower following the CSO vs OO diets.
The present findings underline the value of CSO in improving fasting lipid profiles and its potential in reducing the risk of conditions such as obesity, type 2 diabetes and nonalcoholic fatty liver disease, said researchers.