Most Read Articles
Stephen Padilla, 21 Jul 2017
Adherence to a beneficial lifestyle may significantly reduce the risk of chronic hypertension after hypertensive disorders of pregnancy (HDP) such as gestational hypertension and pre-eclampsia, a recent study suggests. Keeping a healthy weight appears to be critical in women with a history of HDP compared with those without such a history.
Natalia Reoutova, 5 days ago

MitraClip NTR and XTR systems are effective and well tolerated for primary mitral regurgitation (MR), as shown in the prospective, multicentre, single-arm, international, post-marketing, real-world, observational EXPAND study presented at the American College of Cardiology 2020/World Congress of Cardiology (ACC.20/WCC) virtual meeting.

Pearl Toh, 2 days ago
Taking ticagrelor alone — and dropping aspirin — after 3 months of DAPT* post-PCI** significantly reduced bleeding events without increasing the risk of ischaemic adverse events compared with continuing a DAPT of ticagrelor plus aspirin, the TICO*** trial has shown.
09 Jul 2017
The Dietary Approaches to Stop Hypertension (DASH) diet is effective in reducing uric acid concentrations and risks of gout in males, a new prospective cohort study reveals. In contrast, Western diets up the risk of gout.

Diastolic dysfunction tied to increased arterial stiffness in ischaemic stroke patients

23 Feb 2020

One in five young and middle-aged ischaemic stroke survivors (20 percent) have been diagnosed with diastolic dysfunction in a recent study. The presence of diastolic dysfunction correlates with increased arterial stiffness independent of higher age, overweight, hypertension, night-time blood pressure (BP) reduction and left ventricular (LV) mass.

Of the 260 patients with acute ischaemic stroke, 20 percent was found to have prevalent diastolic dysfunction (13 percent with grade 1 and 7 percent grades 2–3). Those with diastolic dysfunction were older and more likely to have hypertension, overweight, increased arterial stiffness, higher LV mass and less percentage nightly reduction in mean BP (pall<0.001).

Furthermore, multivariable logistic regression analysis revealed an association between diastolic dysfunction and increased arterial stiffness (odds ratio, 2.86, 95 percent confidence interval, 1.05–7.79; p<0.05), independent of age >45 years, overweight, hypertension, night-time BP reduction and LV mass.

In this study, the investigators analysed data from 260 patients with acute ischaemic stroke and assessed diastolic dysfunction by combining transmitral peak early floe (E), early diastolic mitral annular velocity (e′), E/e′ ratio, left atrial volume index and peak tricuspid regurgitant jet velocity, following current European guidelines.

Increased arterial stiffness was defined as carotid–femoral pulse wave velocity at least 10 m/s by applanation tonometry.

“Young and middle-aged ischaemic stroke survivors have a high prevalence of hypertension, increased arterial stiffness and abnormal left ventricular (LV) geometry, which all are associated with the presence of LV diastolic dysfunction,” the investigators noted.

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Most Read Articles
Stephen Padilla, 21 Jul 2017
Adherence to a beneficial lifestyle may significantly reduce the risk of chronic hypertension after hypertensive disorders of pregnancy (HDP) such as gestational hypertension and pre-eclampsia, a recent study suggests. Keeping a healthy weight appears to be critical in women with a history of HDP compared with those without such a history.
Natalia Reoutova, 5 days ago

MitraClip NTR and XTR systems are effective and well tolerated for primary mitral regurgitation (MR), as shown in the prospective, multicentre, single-arm, international, post-marketing, real-world, observational EXPAND study presented at the American College of Cardiology 2020/World Congress of Cardiology (ACC.20/WCC) virtual meeting.

Pearl Toh, 2 days ago
Taking ticagrelor alone — and dropping aspirin — after 3 months of DAPT* post-PCI** significantly reduced bleeding events without increasing the risk of ischaemic adverse events compared with continuing a DAPT of ticagrelor plus aspirin, the TICO*** trial has shown.
09 Jul 2017
The Dietary Approaches to Stop Hypertension (DASH) diet is effective in reducing uric acid concentrations and risks of gout in males, a new prospective cohort study reveals. In contrast, Western diets up the risk of gout.