Diagnosis and management of Graves disease
01 Dec 2013
Patients with Graves disease, an autoimmune condition, can be identified by goitre, hyperthyroidism, and in a minority of patients, Grave's opthalmopathy. Measurements of serum levels of TSH-receptor antibodies (TRAb) and thyroid ultrasonography are currently the most important diagnostic tests for Graves’ disease. Present management of the condition comprises of antithyroid drugs or ablative treatments ( 131I-radiotherapy or thyroidectomy). Since the disease process is not targeted by existing management , recurrence or lifelong hypothyroidism may be consequently experienced by patients. Novel agents are currently under preclinical and clinical studies, however, both their efficacy and safety need to be proved.