Most Read Articles
11 May 2020
This second issue revisits the impact EMPA-REG OUTCOME had on clinical practice and helps readers discover how it gives life back to patients through its cardiovascular indication. Learn how it was approved and the possible mechanisms for its cardiovascular benefits.
Pearl Toh, 15 Oct 2020
Cycling was associated with reduced risk for both all-cause and cardiovascular (CV) mortality in people with diabetes, according to a study presented at EASD 2020 Meeting — suggesting that cycling could be encouraged as an activity to prevent deaths in this population who are known to have a higher mortality risk than the general public.
Stephen Padilla, 22 Jul 2019
Zinc supplementation significantly lowers key glycaemic indicators, particularly fasting glucose (FG) in individuals with diabetes and in those who received an inorganic supplement, results of a systematic review and meta-analysis have shown.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

Diabetic polyneuropathy tied to worsening muscle strength in older diabetic patients

21 Jul 2020

Diabetic polyneuropathy (DPN) weakens lower-extremity muscle strength in older type 2 diabetes patients over time, reports a new study.

The study included 51 DPN patients (mean age, 68.9±5.6 years) whose body weight-normalized knee extension force (KEF) was measured at baseline and after an average of 3.6±0.6 years of follow-up. Mobility was also measured using a 25-point locomotive function scale. Health-related quality of life (HRQoL), as assessed by the EuroQol, was set as an additional outcome measure. A parallel group of 54 non-DPN patients were included as comparators.

KEF at baseline was 81.7±30.1 Nm in patients with DPN and 92.5±39.6 Nm in those without. The resulting difference was not statistically significant.

By the follow-up session, the gap in measurement between the two groups had widened, such that those with DPN showed significantly lower KEF (75.4±30.6 vs 91.5±42.2 Nm; p<0.05). A similar pattern of temporal change was reported for relative KEF, which at follow-up had become significantly impaired in DPN patients (1.22±0.47 vs 1.52±0.57 Nm/kg; p<0.01).

This impairment may have contributed to worse HRQoL. DPN patients had significantly lower quality-adjusted life years (QALYs: 0.856±0.131 vs 0.920±0.105; p=0.007). Multiple regression analysis identified an interaction between QALYs and relative KEF at follow-up (p=0.005).

“Further studies are needed to clarify some of these issues and to make further contributions for preventing the need for long-term care and maintaining HRQoL in older patients with type 2 diabetes,” researcher said.

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Most Read Articles
11 May 2020
This second issue revisits the impact EMPA-REG OUTCOME had on clinical practice and helps readers discover how it gives life back to patients through its cardiovascular indication. Learn how it was approved and the possible mechanisms for its cardiovascular benefits.
Pearl Toh, 15 Oct 2020
Cycling was associated with reduced risk for both all-cause and cardiovascular (CV) mortality in people with diabetes, according to a study presented at EASD 2020 Meeting — suggesting that cycling could be encouraged as an activity to prevent deaths in this population who are known to have a higher mortality risk than the general public.
Stephen Padilla, 22 Jul 2019
Zinc supplementation significantly lowers key glycaemic indicators, particularly fasting glucose (FG) in individuals with diabetes and in those who received an inorganic supplement, results of a systematic review and meta-analysis have shown.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.