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01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Yesterday
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.

Diabetic men with high progesterone prone to diabetic retinopathy

05 Dec 2020
Despite being the most preventable diabetes-related complication, Malaysia’s diabetic retinopathy rates are sky high

High serum progesterone is indicative of diabetic retinopathy (DR) in men with type 2 diabetes mellitus (T2DM), a new study finds.

Researchers conducted a cross-sectional analysis of 1,376 male T2DM patients. DR was assessed through fundus examination, slit lamp microscopy, and noninvasive optical coherence tomography. Participants were categorized into three: nonproliferative DR (NPDR), proliferative DR (PDR), and no DR.

Levels of serum progesterone changed significantly across different categories of DR, jumping from a median of 0.68 nmol/L in the no-DR group to 0.86 nmol/L among NPDR patients, and finally to 1.51 nmol/L in men with PDR (p<0.001).

Prolactin, luteinizing hormone, and testosterone also showed significant between-group variability.

Patients were then stratified according to quartiles of serum progesterone. Notable variations were found in the prevalence of DR. NPDR, for example, was significantly more common in the topmost quartile than in the three lower categories (45.4 percent vs 35.2 percent, 31.0 percent, and 33.7 percent; p=0.001).

The same was true for PDR (7.1 percent vs 1.2 percent, 0.9 percent, and 2.3 percent; p<0.001). No DR, on the other hand, saw peak prevalence in the first quartile of serum progesterone and dropped thereafter.

Adjusted logistic regression models confirmed that being in the top quartile of serum progesterone more than doubled the likelihood of having NPDR (odds ratio [OR], 2.13, 95 percent confidence interval [CI], 1.49–3.06; p<0.001) and amplified the odds of PDR by over eight times (OR, 8.44, 95 percent CI, 2.69–26.43; p<0.001).

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Yesterday
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.