Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Diabetes mellitus negatively influences pancreatic cancer outcomes

07 Oct 2019

In pancreatic cancer patients undergoing chemotherapy, the presence of diabetes mellitus is associated with reduced survival and larger tumour, as well as with increased risk of death after treatment, according to a meta-analysis.

Researchers searched multiple online databases for studies evaluating the prognostic impact of diabetes on the clinical outcome of patients with pancreatic cancer following adjuvant chemotherapy. The regimens of chemotherapy and glucose-lowering medications used in the studies were not limited.

The meta-analysis included six case-control studies comprising 4,241 pancreatic cancer patients (median age, >55 years), among whom 1,034 had diabetes. Pancreatic cancer status was advanced or locally advanced, and gemcitabine-based regimens were frequently used for chemotherapy. Diabetes mellitus was either type 1 or type 2, with most patients treated with insulin and metformin.

Pooled data, obtained using a fixed model, revealed significant differences between diabetic pancreatic cancer patients and their nondiabetic counterparts. Specifically, diabetes exerted a negative effect on overall survival (hazard ratio, 1.16, 95 percent CI, 1.08–1.25; p=0.000) and T stage (odds ratio [OR], 1.30, 1.08–2.17; p=0.005) following chemotherapy.

On the other hand, there were no significant between-group differences in gender (OR, 1.23, 1.00–1.50; p=0.051), tumour locations (OR, 1.13, 0.81–1.56; p=0.476), cancer extent (OR, 0.85, 0.48–1.50; p=0.569), N stage (OR, 1.01, 0.58–1.74; p=0.973) and M stage (OR, 0.64, 0.21–1.99; p=0.441).

According to the researchers, further research is warranted to explore the biological mechanisms underlying the present observations, which may offer new opportunities for diagnosis and therapy in pancreatic cancer and diabetes mellitus patients.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.