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Diabetes mellitus negatively influences pancreatic cancer outcomes

07 Oct 2019

In pancreatic cancer patients undergoing chemotherapy, the presence of diabetes mellitus is associated with reduced survival and larger tumour, as well as with increased risk of death after treatment, according to a meta-analysis.

Researchers searched multiple online databases for studies evaluating the prognostic impact of diabetes on the clinical outcome of patients with pancreatic cancer following adjuvant chemotherapy. The regimens of chemotherapy and glucose-lowering medications used in the studies were not limited.

The meta-analysis included six case-control studies comprising 4,241 pancreatic cancer patients (median age, >55 years), among whom 1,034 had diabetes. Pancreatic cancer status was advanced or locally advanced, and gemcitabine-based regimens were frequently used for chemotherapy. Diabetes mellitus was either type 1 or type 2, with most patients treated with insulin and metformin.

Pooled data, obtained using a fixed model, revealed significant differences between diabetic pancreatic cancer patients and their nondiabetic counterparts. Specifically, diabetes exerted a negative effect on overall survival (hazard ratio, 1.16, 95 percent CI, 1.08–1.25; p=0.000) and T stage (odds ratio [OR], 1.30, 1.08–2.17; p=0.005) following chemotherapy.

On the other hand, there were no significant between-group differences in gender (OR, 1.23, 1.00–1.50; p=0.051), tumour locations (OR, 1.13, 0.81–1.56; p=0.476), cancer extent (OR, 0.85, 0.48–1.50; p=0.569), N stage (OR, 1.01, 0.58–1.74; p=0.973) and M stage (OR, 0.64, 0.21–1.99; p=0.441).

According to the researchers, further research is warranted to explore the biological mechanisms underlying the present observations, which may offer new opportunities for diagnosis and therapy in pancreatic cancer and diabetes mellitus patients.

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Most Read Articles
6 days ago
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 6 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Yesterday
Percutaneous coronary intervention (PCI), compared with coronary artery bypass grafting (CABG), in the revascularization of left main coronary artery (LMCA) disease may lead to death, myocardial infarction (MI), or stroke in patients with moderate or severe left ventricular (LV) dysfunction, reveals a study.