Most Read Articles
Elvira Manzano, 13 Apr 2020
A gout drug that’s been around for years reduced the risk of ischaemic cardiovascular (CV) events when given at a low dose in patients who had myocardial infarction (MI) and was cost-effective, an analysis of the COLCOT* trial has shown.
Pearl Toh, 23 Apr 2020
Taking ticagrelor alone — and dropping aspirin — after 3 months of DAPT* post-PCI** significantly reduced bleeding events without increasing the risk of ischaemic adverse events compared with continuing a DAPT of ticagrelor plus aspirin, the TICO*** trial has shown.
Roshini Claire Anthony, 17 Jul 2020

Icosapent ethyl may reduce the risk of cardiovascular (CV) events in patients with diabetes mellitus (DM) taking statins, according to findings of REDUCE-IT DIABETES presented at ADA 2020.

Elaine Soliven, 12 Apr 2019
The use of catheter ablation as first-line treatment reduces the number of premature ventricular complexes (PVCs) in a paediatric population, according to a study presented at EHRA 2019.

Diabetes contributes to increased stroke risk independent of CAD

15 Nov 2019

Diabetes mellitus (DM) carries an increased hazard of ischaemic stroke in patients with or without atrial fibrillation even in the absence of coronary artery disease (CAD), a study has found.

Researchers looked at a cohort of 81,909 patients who underwent coronary angiography, none of whom had been previously diagnosed with ischaemic stroke or transient ischaemic attack (TIA). Follow-up started 30 days after coronary angiography, and the median duration was 3.8 years.

In the cohort, 12,521 patients (15.3 percent) had diabetes, among whom 8,988 (11.0 percent) had CAD and 3,533 (4.3 percent) had no CAD. The respective number of those with and without CAD among patients without diabetes were 42,319 (51.7 percent) and 27,069 (33.0 percent).

Ischaemic stroke rates increased accordingly with the number of exposures, such that patients with neither CAD nor DM had the lowest risk (0.52 events per 100 person-years), those with CAD alone or DM alone had intermediate risk (0.77 and 0.95 events, respectively, per 100 person-years), and those with both DM and CAD had the highest risk (1.32 events per 100 person-years).

The adjusted incidence rate ratios for ischaemic stroke vs patients with neither DM nor CAD were 2.00 (95 percent confidence interval [CI], 1.72–2.32) in the group of patients with both DM and CAD, 1.27 (95 percent CI, 1.12–1.44) in the CAD-alone group and 1.74 (95 percent CI, 1.42–2.15) in the DM-alone group.

Among patients with DM, CAD extent further predicted the risk of ischaemic stroke (p-trend<0.001).

Results were similar for the composite endpoint of ischaemic stroke, TIA and systemic embolism, and did not differ between patients with and without AF.

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Most Read Articles
Elvira Manzano, 13 Apr 2020
A gout drug that’s been around for years reduced the risk of ischaemic cardiovascular (CV) events when given at a low dose in patients who had myocardial infarction (MI) and was cost-effective, an analysis of the COLCOT* trial has shown.
Pearl Toh, 23 Apr 2020
Taking ticagrelor alone — and dropping aspirin — after 3 months of DAPT* post-PCI** significantly reduced bleeding events without increasing the risk of ischaemic adverse events compared with continuing a DAPT of ticagrelor plus aspirin, the TICO*** trial has shown.
Roshini Claire Anthony, 17 Jul 2020

Icosapent ethyl may reduce the risk of cardiovascular (CV) events in patients with diabetes mellitus (DM) taking statins, according to findings of REDUCE-IT DIABETES presented at ADA 2020.

Elaine Soliven, 12 Apr 2019
The use of catheter ablation as first-line treatment reduces the number of premature ventricular complexes (PVCs) in a paediatric population, according to a study presented at EHRA 2019.