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Diabetes, mood disorders prevalent in plaque palmoplantar psoriasis

15 Mar 2021

Several comorbidities associated with psoriasis vulgaris are also prevalent in patients with plaque palmoplantar psoriasis (PPP), a recent study has found. In addition, individuals with PPP have a particularly high risk for mood disorders.

To examine the association between PPP and comorbidities known to be associated with generalized plaque psoriasis, the authors retrospectively compared the prevalence of comorbidities previously found to be associated with generalized plaque psoriasis among 163 patients with PPP who had been treated with topical psoralen and ultraviolet A from 2009 to 2017 and a cohort of 781 controls.

Each patient with psoriasis was matched according to sex and age with up to five controls. Associations were assessed after matching using conditional logistic regression.

The following comorbidities significantly correlated with PPP: diabetes mellitus (odds ratio [OR], 2.296), cardiovascular disease (OR, 1.797), and mood disorders (OR, 6.232). Furthermore, hypertension, dyslipidaemia, and psoriatic arthritis were more frequent among patients with PPP, but such associations were not statistically significant.

This study was limited by its retrospective nature, the collection of some data through a survey questionnaire, and the relatively small sample size, which suggested the need to validate the present data in a prospective manner, according to the authors

“Additionally, within the psoriasis group, patients were assessed for the presence of comorbidities during the whole follow-up period, whereas the comorbidities of individuals in the control group were assessed during a baseline visit,” they added.

“Psoriasis has been shown to be associated with several comorbidities,” the authors noted.

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Most Read Articles
Pearl Toh, 4 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Elvira Manzano, 3 days ago
An investigational transdermal amphetamine patch worn for 9 hours on the hip appeared effective in paediatric patients with attention deficit-hyperactivity disorder (ADHD) in a phase II, two-part trial.
Tristan Manalac, 5 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.