Most Read Articles
Pearl Toh, 5 days ago
A study finds no evidence that using pharmaceutical aids alone for smoking cessation helps improve the chances of successful quitting despite promising results in previous randomized trials and routine prescription of such drugs to help quit smoking.
Elvira Manzano, 2 days ago
Cancer patients at risk for recurrent venous thromboembolism (VTE) are less likely to experience recurrence with rivaroxaban compared with dalteparin, the Select-D trial has shown, ushering in a new standard of care (SoC) for cancer-related VTE.
6 days ago

It appears that patients with rheumatoid arthritis (RA) are at an increased risk of obstructive sleep apnoea (OSA) secondary to both traditional and RA-related risk factors, a recent study has found.

Yesterday
Weight loss medications that have received the Food and Drug Administration (FDA) approval appear to confer only modest positive benefits for cardiometabolic risk profile, according to a study.

DHA supplementation eases placental inflammation in obese pregnant women

08 Jan 2018

Maternal supplementation of docosahexaenoic acid (DHA) during pregnancy reduces placental inflammation and differentially modulates placental nutrient transport capacity, according to a study. It may also attenuate adverse effects of maternal obesity on placental function.

DHA supplementation elevated erythrocyte (p<0.0001) and placental membrane DHA levels (p<0.0001) but appeared to have no effect on maternal inflammatory status, insulin sensitivity or lipids. In addition, DHA supplementation lessened placental inflammation, amino acid transporter expression and activity, as well as increased placental protein expression of fatty acid transporting protein 4 (p<0.05).

A total of 38 obese pregnant women were supplemented with DHA (800 mg, algal oil) or placebo (corn/soy oil) daily from 26 weeks to term in an academic healthcare institution to determine the effects of DHA supplementation on maternal metabolism and placental function. The authors collected maternal fasting blood at 26 and 36 weeks’ gestation, and placentas at term.

DHA content of maternal erythrocyte and placental membranes, maternal fasting blood glucose, cytokines, metabolic hormones, and circulating lipids were determined. The authors evaluated insulin, mTOR and inflammatory signalling in placental homogenates, and determined nutrient transport capacity in isolated syncytiotrophoblast plasma membranes.

In one study, researchers found that supplementation with omega-3 fatty acids during pregnancy in overweight and obese women inhibited the placenta from esterifying and storing lipids. [Am J Clin Nutr 2016;103:1064-1072]

“Maternal obesity in pregnancy has profound impacts on maternal metabolism and promotes placental nutrient transport, which may contribute to foetal overgrowth in these pregnancies,” the authors said. “The fatty acid DHA has bioactive properties that may improve outcomes in obese pregnant women by modulating placental function.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Pearl Toh, 5 days ago
A study finds no evidence that using pharmaceutical aids alone for smoking cessation helps improve the chances of successful quitting despite promising results in previous randomized trials and routine prescription of such drugs to help quit smoking.
Elvira Manzano, 2 days ago
Cancer patients at risk for recurrent venous thromboembolism (VTE) are less likely to experience recurrence with rivaroxaban compared with dalteparin, the Select-D trial has shown, ushering in a new standard of care (SoC) for cancer-related VTE.
6 days ago

It appears that patients with rheumatoid arthritis (RA) are at an increased risk of obstructive sleep apnoea (OSA) secondary to both traditional and RA-related risk factors, a recent study has found.

Yesterday
Weight loss medications that have received the Food and Drug Administration (FDA) approval appear to confer only modest positive benefits for cardiometabolic risk profile, according to a study.