Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, 23 hours ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.

DHA supplementation eases placental inflammation in obese pregnant women

08 Jan 2018

Maternal supplementation of docosahexaenoic acid (DHA) during pregnancy reduces placental inflammation and differentially modulates placental nutrient transport capacity, according to a study. It may also attenuate adverse effects of maternal obesity on placental function.

DHA supplementation elevated erythrocyte (p<0.0001) and placental membrane DHA levels (p<0.0001) but appeared to have no effect on maternal inflammatory status, insulin sensitivity or lipids. In addition, DHA supplementation lessened placental inflammation, amino acid transporter expression and activity, as well as increased placental protein expression of fatty acid transporting protein 4 (p<0.05).

A total of 38 obese pregnant women were supplemented with DHA (800 mg, algal oil) or placebo (corn/soy oil) daily from 26 weeks to term in an academic healthcare institution to determine the effects of DHA supplementation on maternal metabolism and placental function. The authors collected maternal fasting blood at 26 and 36 weeks’ gestation, and placentas at term.

DHA content of maternal erythrocyte and placental membranes, maternal fasting blood glucose, cytokines, metabolic hormones, and circulating lipids were determined. The authors evaluated insulin, mTOR and inflammatory signalling in placental homogenates, and determined nutrient transport capacity in isolated syncytiotrophoblast plasma membranes.

In one study, researchers found that supplementation with omega-3 fatty acids during pregnancy in overweight and obese women inhibited the placenta from esterifying and storing lipids. [Am J Clin Nutr 2016;103:1064-1072]

“Maternal obesity in pregnancy has profound impacts on maternal metabolism and promotes placental nutrient transport, which may contribute to foetal overgrowth in these pregnancies,” the authors said. “The fatty acid DHA has bioactive properties that may improve outcomes in obese pregnant women by modulating placental function.”

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Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, 23 hours ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.