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DHA plus vitamin E supplementation improves sperm motility in men

22 Sep 2020

Coadministration of DHA and vitamin E supplements results in increased sperm motility, but no significant changes have been observed in sperm morphology and vitality in asthenozoospermic men, a study has shown.

This factorial, randomized, double-blind, placebo-controlled trial was conducted in infertility clinics in Tehran, Iran, and included idiopathic asthenozoospermic men aged 20–45 years with normal endocrine function. The concentration of spermatozoa and percentage of morphologically normal spermatozoa among participants were equal to or above the lower reference limits, according to the fifth edition of the World Health Organization guideline.

Of the 717 men referred to infertility clinics, 180 asthenozoospermic men were randomized to one of four groups based on stratified blocked randomization by age and sperm concentration. Participants took daily 465 mg DHA plus 600 IU vitamin E (DE), 465 mg DHA plus placebo (DP), 600 IU vitamin E plus placebo (EP), or both placebo capsules (PP) for 12 weeks.

The investigators then measured sperm characteristics, oxidative stress of seminal plasma, serum and sperm membrane fatty acids, dietary intakes, anthropometric measurements, and physical activity at baseline and after 12 weeks.

The DE group showed greater mean sperm progressive motility (27.9±2.8) than in the DP (25.7±3.4), EP (26.1±2.8), and PP (25.8±2.6) groups (p<0.05) after the intervention. The DE group also had significantly increased sperm count (p=0.001) and concentration (p=0.044) compared with the other three groups, but no significant between-group difference was noted in other semen parameters after the intervention.

Finally, serum concentrations of n–3 polyunsaturated fatty acids were significantly higher in the DE and DP groups than in the EP and PP groups.

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Most Read Articles
Jairia Dela Cruz, 05 Oct 2020
Drinking more than two cups of coffee per day may just be the intervention that prevents hundreds of thousands of liver disease‐related deaths globally, a study reports.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

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