Most Read Articles
3 days ago
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, Yesterday
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Cognitive deficits in bipolar disorder are neurodevelopmental rather than neurodegenerative in nature, a recent study has reported. Furthermore, cognitive impairment in bipolar patients appears to be stable, in the majority at least.
2 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.

Devascularized parenchymal mass tied to functional outcome after partial nephrectomy

27 Sep 2017

Devascularized, compared with excised, parenchymal mass has more impact on functional recovery following partial nephrectomy, and this may have implications with respect to surgical technique, a recent study has found.

“Parenchymal mass loss is the predominant factor associated with functional outcomes after partial nephrectomy. It is primarily due to excised and/or devascularized parenchymal mass,” researchers said.

Researchers analysed a total of 168 patients who underwent partial nephrectomy to determine excised and devascularized parenchymal mass and to assess parenchymal mass changes and functional loss of the operated kidney. They also measured parenchymal mass loss in the ipsilateral kidney on contrast-enhanced computed tomography <2 months before and 3 to 12 months after partial nephrectomy.

Excised parenchymal mass was defined as specimen volume minus tumour volume. Devascularized parenchymal mass was estimated by subtracting excised parenchymal mass from total parenchymal mass loss.

Pearson correlation was used to assess relationships between glomerular filtration rate preservation and parenchymal mass loss. Researchers used multivariable analysis to evaluate factors linked to devascularized parenchymal mass.

Median R.E.N.A.L. (radius, exophytic/endophytic tumour properties, nearness of tumour to collecting system or sinus, anterior/posterior and location relative to polar lines) was 7 and median tumour size was 3.4 cm. Warm ischaemia was used in 100 patients and cold ischaemia in 68.

Median devascularized parenchymal mass was 16 cm3 and median excised parenchymal mass 9 cm3 (p<0.001). Total parenchymal mass loss and devascularized parenchymal mass strongly correlated with glomerular filtration rate preservation in the operated kidney (r≥0.55; p<0.001 for both). However, only a weak association existed between excised parenchymal mass and functional outcomes (r=0.23).

Multivariable analysis revealed that the preoperative glomerular filtration rate and endophytic status were associated with devascularized parenchymal mass.

“Prospective study is required to further evaluate the relative contributions of excised and devascularized parenchymal mass in various settings,” researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
3 days ago
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, Yesterday
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Cognitive deficits in bipolar disorder are neurodevelopmental rather than neurodegenerative in nature, a recent study has reported. Furthermore, cognitive impairment in bipolar patients appears to be stable, in the majority at least.
2 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.