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Desmoid tumour patients suffer from high emotional distress

04 Jan 2020

The burden of emotional distress is high among adults with desmoid tumours (DT), particularly in women and in patients with a history of mood problems, a new study reports.

Researchers enrolled 94 DT patients (mean age, 40 years; 78 percent female) who completed the Distress Assessment and Response Tool (DART) at four distinct time points: at diagnosis (T1), during treatment (T2) and at <6 (T3) and 6 (T4) months after treatment. DART scores also reported physical symptoms, depression, anxiety and social difficulties.

A total of 152 DART screens were included in the analysis. Almost half of the DT cases were located in the abdominal wall (48 percent); the extremities (30 percent) and mesentery (22 percent) were also common sites.

Significant longitudinal changes were reported for the patient symptoms of appetite (p=0.02), drowsiness (p=0.04) and tiredness (p=0.01), which peaked during treatment and decreased thereafter. The proportion of patients who were of poor wellbeing was consistently high across all time points (T1: 36 percent; T2: 45 percent; T3: 50 percent; T4: 31 percent; p=0.47).

The prevalence of moderate-to-severe levels of emotional distress likewise remained relatively stable at all time points, such that rates of anxiety ranged from 34 percent at T1 to 20 percent at T4 (p=0.44). The same was true for depression (T1: 25 percent; T2: 29 percent; T3: 27 percent; T4: 13 percent; p=0.63).

Multivariable regression analysis found that DT located at the abdominal wall was a significant predictor of distress, as were being a woman, having a personal history of mood problems, having difficulty with treatment decisions and problems with information about available resources.

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Most Read Articles
Stephen Padilla, 06 Aug 2020
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
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Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.