Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 5 days ago
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.
6 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.

Desmoid tumour patients suffer from high emotional distress

04 Jan 2020

The burden of emotional distress is high among adults with desmoid tumours (DT), particularly in women and in patients with a history of mood problems, a new study reports.

Researchers enrolled 94 DT patients (mean age, 40 years; 78 percent female) who completed the Distress Assessment and Response Tool (DART) at four distinct time points: at diagnosis (T1), during treatment (T2) and at <6 (T3) and 6 (T4) months after treatment. DART scores also reported physical symptoms, depression, anxiety and social difficulties.

A total of 152 DART screens were included in the analysis. Almost half of the DT cases were located in the abdominal wall (48 percent); the extremities (30 percent) and mesentery (22 percent) were also common sites.

Significant longitudinal changes were reported for the patient symptoms of appetite (p=0.02), drowsiness (p=0.04) and tiredness (p=0.01), which peaked during treatment and decreased thereafter. The proportion of patients who were of poor wellbeing was consistently high across all time points (T1: 36 percent; T2: 45 percent; T3: 50 percent; T4: 31 percent; p=0.47).

The prevalence of moderate-to-severe levels of emotional distress likewise remained relatively stable at all time points, such that rates of anxiety ranged from 34 percent at T1 to 20 percent at T4 (p=0.44). The same was true for depression (T1: 25 percent; T2: 29 percent; T3: 27 percent; T4: 13 percent; p=0.63).

Multivariable regression analysis found that DT located at the abdominal wall was a significant predictor of distress, as were being a woman, having a personal history of mood problems, having difficulty with treatment decisions and problems with information about available resources.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 5 days ago
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.
6 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.