Most Read Articles
Roshini Claire Anthony, 3 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Stephen Padilla, 6 days ago
Brodalumab has exhibited long-term efficacy and consistent safety profile for more than 2 years in the treatment of patients with psoriasis, results of the phase III AMAGINE-2 trial show.
19 Jan 2020
Anaemia increases mortality risk in heart failure (HF) patients across the ejection fraction (EF) spectrum, a recent study has found. The effect appears to be stronger in preserved (HFpEF) and midrange (HFmrEF) than in reduced (HFrEF) EF disease.

Desmetramadol a safer, more effective analgesic than tramadol

19 Oct 2019
Healthcare providers to educate the public and promote awareness of the consequences of paracetamol overdose

Desmetramadol is able to provide the analgesic benefits of tramadol without the associated metabolic liabilities, according to a recent series of trials.

The study involved two consecutive randomized, double-blind, three-period cross-over, placebo- and active comparator-controlled trials. Researchers randomly assigned 103 healthy participants to receive 50 mg tramadol and 20 mg desmetramadol either with (trial A; n=43; mean age, 28.4±8.0 years; 100 percent male) or without (trial B; n=60; mean age, 28.0±6.8 years; 70 percent male) cotreatment with paroxetine.

In trial A, participants treated with tramadol (mean change, –0.46±0.19; p=0.022) and desmetramadol (mean change, –0.60±0.15; p=0.0005) exhibited significant decreases in average cold-induced pain perception at 30 seconds relative to placebo controls. No significant differences were reported when the two active treatments were compared against each other (p=0.47).

In the male subgroup of trial B, tramadol failed to produce significantly better analgesia relative to placebo (p=0.90), while desmetramadol significantly outperformed both tramadol (p=0.003) and placebo (p=0.036).

Moreover, in the presence of paroxetine, desmetramadol provided 44-percent longer pain tolerance duration relative to placebo than did tramadol.

In trial A, tramadol and desmetramadol showed comparable safety profiles. Cotreatment with paroxetine seemed to result in fewer adverse events.

“Desmetramadol thus obviates the metabolic liabilities of tramadol while preserving its safety profile, because it does not rely on the activity of CYP enzymes for its activity,” said researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 3 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Stephen Padilla, 6 days ago
Brodalumab has exhibited long-term efficacy and consistent safety profile for more than 2 years in the treatment of patients with psoriasis, results of the phase III AMAGINE-2 trial show.
19 Jan 2020
Anaemia increases mortality risk in heart failure (HF) patients across the ejection fraction (EF) spectrum, a recent study has found. The effect appears to be stronger in preserved (HFpEF) and midrange (HFmrEF) than in reduced (HFrEF) EF disease.