Most Read Articles
Roshini Claire Anthony, 6 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

6 days ago
Patients with coronary artery disease (CAD) treated in a poor Southeast Asian setting appear to have far too high short-term and medium-term mortality rates, according to a study.
4 days ago
Heeding the advice to eat more vegetables has led to an increase in consumption above the Australian Dietary recommendation of ~375 g/day among overweight participants, a recent study has shown. Tomatoes are a common choice regardless of the time of year, but selections change over time.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.

Depressive symptoms predict future disability, pain in adolescent JIA patients

25 May 2018

In adolescent juvenile idiopathic arthritis (JIA) patients, depressive symptoms are prevalent and predictive of future pain and disability, a study has found.

The study included 102 JIA patients (median age 13.2 years; 56.9 percent female). Assessments included depressive symptoms (Mood and Feelings Questionnaire [MFQ]), active and limited joint count, disability score (Childhood Health Assessment Questionnaire), pain visual analogue scale, and patient’s general evaluation visual analogue scale.

At baseline, a significant number of patients had low mood, with 14.7 percent scoring over the MFQ cutoff for major depressive disorder. Multiple linear regression revealed that baseline depressive symptoms were significantly associated with all clinical measures of disease (p0.01).

Of note, high baseline depressive symptoms scores emerged as predictors of worse pain (p0.005) and disability (p0.001), but not active and limited joint counts, at 12 months after index consultation.

Findings of the present study support active screening for depressive symptoms in routine clinical practice, as well as underscore the need for a psychological intervention study with the aim of improving long-term outcomes for adolescents with JIA.

According to researchers, the association between active inflammatory disease and depressive symptoms may be partially explained by the inflammatory theory of depression, which states that depression can be triggered by peripheral inflammation. This indicates that patients with chronic inflammatory diseases, including JIA, may have increased susceptibility to depression.

However, researchers also acknowledged that the directionality behind the association between inflammation and depression, while unclear, is likely to be multifactorial and bidirectional.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

6 days ago
Patients with coronary artery disease (CAD) treated in a poor Southeast Asian setting appear to have far too high short-term and medium-term mortality rates, according to a study.
4 days ago
Heeding the advice to eat more vegetables has led to an increase in consumption above the Australian Dietary recommendation of ~375 g/day among overweight participants, a recent study has shown. Tomatoes are a common choice regardless of the time of year, but selections change over time.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.