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Depression tied to work, school absenteeism in patients with chronic constipation

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Depression appears to be a stronger predictor of absenteeism than symptom severity in patients with chronic constipation, suggests a study, adding that depression may partly contribute to the indirect costs of chronic constipation.

Of the 148 consecutive patients (mean age 43 years; 87 percent female) enrolled in the study, 32 (21.6 percent) had high absenteeism and 36 (24.3 percent) visited the emergency department (ED) for constipation in the past year. Depression was likely in patients with high absenteeism (56.3 percent vs 18.5 percent; p<0.0001) and ED visits (47.2 percent vs 19.6 percent; p<0.01).

Multivariable adjustment and sensitivity analyses revealed that only depression (odds ratio [OR], 4.41; p<0.01) correlated with increased absenteeism, while a trend toward an association between depression and ED visits (OR, 2.57; p=0.067) was observed. In addition, no association was observed between symptom severity and high absenteeism or ED utilization.

The investigators carried out a cross-sectional cohort study of patients with chronic constipation who presented to a tertiary care centre for anorectal manometry to determine patient characteristics related to increased absenteeism and ED utilization.

Standardized instruments were used to evaluate disease severity, quality of life, somatization and psychiatric comorbidities. Multivariable logistic regression was used to determine the predictors of work and school absenteeism as well as ED visits for constipation.

“Chronic constipation is associated with significant direct and indirect economic costs,” the investigators said. “There has been limited study of the predictors of direct and indirect costs in a population with refractory constipation.”

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Most Read Articles
06 Jul 2020
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
Roshini Claire Anthony, 6 days ago

Upadacitinib may be a suitable treatment for patients with active psoriatic arthritis (PsA) who have insufficient response to non-biologic disease-modifying anti-rheumatic drugs (non-bDMARDs), according to results of the phase III SELECT-PsA-1* trial presented at EULAR 2020.

5 days ago
Maternal stress during pregnancy correlates with rapid weight gain of her infant, a recent study has found.