Most Read Articles
6 days ago
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 4 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
5 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.

Depression, anxiety negatively predict joint remission in RA, PsA

19 Aug 2017

Depression and anxiety appear to reduce the likelihood of achieving joint remission in rheumatoid arthritis (RA) and, partly, in psoriatic arthritis (PsA), according to a study.

Researchers examined 1,326 patients with RA and 728 patients with PsA from the prospective observational Norwegian Disease-Modifying Anti-Rheumatic Drug study. All patients had initiated first-time tumour necrosis factor inhibitors (TNFi) or methotrexate (MTX).

Prespecified logistic and multiple linear regression models were used to estimate the predictive value of depression/anxiety on remission and test the associations between baseline depression/anxiety and the components of the remission criteria.

The number of patients with depression/anxiety was 573 in the RA group (mean age 53.5 years; 75.1 percent) and 326 in the PsA group (mean age 46.9 years; 59.7 percent).

Baseline depression/anxiety negatively predicted 28-joint Disease Activity Score <2.6, Simplified Disease Activity Index ≤3.3, Clinical Disease Activity Index ≤2.8, ACR/EULAR Boolean and Disease Activity Index for Psoriatic Arthritis ≤4 remission after 3 and 6 months of treatment in RA. Corresponding findings in PsA also showed consistently lower point estimates but did not reach significance for all the analyses.

Moreover, baseline depression/anxiety correlated with increased patient’s and evaluator’s global assessment, tender joint count and joint pain in RA at follow-up, as well as with increased patient’s and evaluator’s global assessment in PsA, but not with swollen joint count and acute phase reactants.

The findings were robust across different depression/anxiety and remission criteria, as well as in subgroup analyses of TNFi- and MTX-treated patients.

Psychiatric conditions such as depression and anxiety should be taken into account in individual RA or PsA patients when making a shared decision on a treatment target, researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
6 days ago
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 4 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
5 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.