Most Read Articles
Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Depression, anxiety negatively predict joint remission in RA, PsA

19 Aug 2017

Depression and anxiety appear to reduce the likelihood of achieving joint remission in rheumatoid arthritis (RA) and, partly, in psoriatic arthritis (PsA), according to a study.

Researchers examined 1,326 patients with RA and 728 patients with PsA from the prospective observational Norwegian Disease-Modifying Anti-Rheumatic Drug study. All patients had initiated first-time tumour necrosis factor inhibitors (TNFi) or methotrexate (MTX).

Prespecified logistic and multiple linear regression models were used to estimate the predictive value of depression/anxiety on remission and test the associations between baseline depression/anxiety and the components of the remission criteria.

The number of patients with depression/anxiety was 573 in the RA group (mean age 53.5 years; 75.1 percent) and 326 in the PsA group (mean age 46.9 years; 59.7 percent).

Baseline depression/anxiety negatively predicted 28-joint Disease Activity Score <2.6, Simplified Disease Activity Index ≤3.3, Clinical Disease Activity Index ≤2.8, ACR/EULAR Boolean and Disease Activity Index for Psoriatic Arthritis ≤4 remission after 3 and 6 months of treatment in RA. Corresponding findings in PsA also showed consistently lower point estimates but did not reach significance for all the analyses.

Moreover, baseline depression/anxiety correlated with increased patient’s and evaluator’s global assessment, tender joint count and joint pain in RA at follow-up, as well as with increased patient’s and evaluator’s global assessment in PsA, but not with swollen joint count and acute phase reactants.

The findings were robust across different depression/anxiety and remission criteria, as well as in subgroup analyses of TNFi- and MTX-treated patients.

Psychiatric conditions such as depression and anxiety should be taken into account in individual RA or PsA patients when making a shared decision on a treatment target, researchers said.

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Most Read Articles
Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.