Most Read Articles
11 Aug 2020
During the Allergic Rhinitis (AR) Boot Camp held in conjunction with the Bayer Pharmacist Congress 2020, Professor Dr Baharudin Abdullah discussed the management of AR in the primary care setting and the importance of using patient profiles to guide the choice of antihistamines.
Elaine Soliven, 4 days ago
Adding mepolizumab to standard of care treatment significantly reduces nasal polyp size and obstruction in adults with chronic rhinosinusitis with nasal polyps (CRSwNP), according to the SYNAPSE* study presented at ERS 2020.
6 days ago
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Audrey Abella, 11 Sep 2020
A prasugrel de-escalation strategy significantly reduced the risk of NACE* and bleeding events in patients with ACS** after PCI*** compared with the conventional strategy, results of the HOST-REDUCE-POLYTECH-ACS# trial have shown.

Denosumab exerts delaying effects on skeletal-related events in at-risk cancer patients

08 Aug 2020

Denosumab bests zoledronic acid (ZA) at preventing skeletal-related events (SREs) in vulnerable cancer patients, according to the results of a meta-analysis. The former also shows a better tolerability profile despite being associated with potential yet manageable adverse events (AEs).

Researchers searched multiple online databases for randomized controlled trials that assessed the efficacy and tolerability of denosumab 120-mg injection vs ZA 4-mg drip, given every 4 weeks, in multiple myeloma patients with bone lesions or in patients with bone metastases secondary to advanced solid tumours.

Four trials were included in the meta-analysis, and the total population comprised 7,379 patients: 3,691 in the denosumab group and 3,688 in the ZA group. There were no significant between-group differences seen in most baseline characteristics. The quality of the trials varied from moderate to high, as shown in the Cochrane risk for bias assessment tool.

Pooled data revealed the superiority of denosumab over ZA in terms of delaying the incidence of a first SRE (hazard ratio [HR], 0.86, 95 percent confidence interval [CI], 0.80–0.93; p=0.0001), as well as that of a subsequent SRE (at least 21 days after the first SRE; HR, 0.83, 95 percent CI, 0.76–0.90; p<0.0001). However, overall survival and disease progression were similar in the two treatment groups.

Denosumab also conferred substantial benefits for bone pain (risk ratio [RR], 0.88, 95 percent CI, 0.80–0.97; p=0.01), osteonecrosis of the jaw (RR, 0.75, 95 percent CI, 0.61–0.93; p=0.007), and acute-phase reactions (RR, 0.47, 95 percent CI, 0.40–0.56; p<0.00001).

In view of the findings, the researchers suggested that a RANKL inhibitor be considered the standard of care in preventing SREs, particularly in patients with renal insufficiency. Future studies should evaluate quality-of-life measures in patients with bone lesions in myeloma and bone metastases secondary to solid tumours.

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Most Read Articles
11 Aug 2020
During the Allergic Rhinitis (AR) Boot Camp held in conjunction with the Bayer Pharmacist Congress 2020, Professor Dr Baharudin Abdullah discussed the management of AR in the primary care setting and the importance of using patient profiles to guide the choice of antihistamines.
Elaine Soliven, 4 days ago
Adding mepolizumab to standard of care treatment significantly reduces nasal polyp size and obstruction in adults with chronic rhinosinusitis with nasal polyps (CRSwNP), according to the SYNAPSE* study presented at ERS 2020.
6 days ago
OZEMPIC – Semaglutide 1.34 mg/mL soln for inj
Audrey Abella, 11 Sep 2020
A prasugrel de-escalation strategy significantly reduced the risk of NACE* and bleeding events in patients with ACS** after PCI*** compared with the conventional strategy, results of the HOST-REDUCE-POLYTECH-ACS# trial have shown.