Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
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At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
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Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.

Delirium may be a red flag for dementia in older people

26 Oct 2019

In hospitalized older adults with acute illness, the incidence of delirium carries a twofold greater odds of developing dementia postdischarge, a retrospective study has found.

Researchers reviewed the medical records of 309 acutely ill elderly patients (mean age, 78 years; 60 percent female). None of the patients showed cognitive decline on admission.

Delirium was detected in 66 patients (21 percent). These patients were more likely to be totally dependent for activities of daily living (44 percent vs 14 percent; p<0.001), malnourished (36 percent vs 24 percent; p<0.001), have higher levels of C-reactive protein (78 vs 51 g/dL; p=0.005) and lower levels of serum albumin on admission (3.04 vs 3.35 mg/dL; p=0.001).

After a median follow-up of 24 months, 21 patients (32 percent) who had experienced delirium developed dementia, while only 38 patients (16 percent) of those without delirium had the same outcome (p=0.003).

Multivariate competing-risk proportional-hazard models showed delirium to be independently associated with postdischarge dementia, yielding a subhazard ratio of 1.94 (95 percent CI, 1.10–3.44; p=0.022).

The findings suggest that delirium is as an independent and potentially preventable risk factor for cognitive decline, highlighting the importance of systematic initiatives to fight the syndrome, according to the researchers. Additional studies on the possible biomarkers and neuropathologic substrata of the delirium-to-dementia pathway, as well as clinical trials exploring whether delirium prevention effectively reduces incident dementia, are needed.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 6 days ago
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.
12 Jan 2020
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.