Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
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Delirium clouds survival outlook in older COVID-19 patients

20 Dec 2020

Delirium is a common occurrence among older adults hospitalized for the novel coronavirus disease (COVID-19), a recent study has found. In turn, delirium seems to worsen mortality risk.

Researchers conducted a multicentre observational cohort study of 516 COVID-19 patients (median age, 78 years; 62 percent male). Delirium on admission was identified using the Diagnostic and Statistical Manual of Mental Disorders, modified Richmond Agitation Sedation Scale, the 4 A’s Test (4-AT), or a physician’s clinical impression.

Seventy-three patients were found to have delirium upon admission, resulting in a prevalence rate of 14.1 percent. These patients were, on average, 7 years older than the no-delirium comparators, were on more prescription medication, and had a greater number of pre-existing diseases.

Multivariable regression analysis identified dementia, having more chronic diseases, and opacities on chest x-ray or computed tomography as significant correlates for delirium.

Over a median follow-up of 19 days, 37 percent (n=191) of the patients died, 278 were discharged to their homes, and 47 were transferred to other care centres of lower-intensity wards. At 30 days from admission, 38 and 145 patients in the delirium and comparator groups died, respectively. The corresponding rates were 53.2 percent and 33.8 percent (p<0.001).

At the same time point, 24.2 percent and 50.1 percent of the patients in the respective groups were discharged from the hospital.

Fully adjusted Cox regression analysis showed that delirium doubled the risk of in-hospital mortality (hazard ratio, 2.00, 95 percent confidence interval, 1.23–3.25).

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
2 days ago
Among patients with moderate-to-severe psoriasis, the use of biologics appears to lower the risk of being hospitalized for the novel coronavirus disease (COVID-19), a new study has found.